CD137 (4-1BB) 和 T 淋巴细胞耗竭。
CD137 (4-1BB) and T-Lymphocyte Exhaustion.
发表日期：2024 Aug 09
作者：
Paula Molero-Glez, Arantza Azpilikueta, Laura Mosteo, Javier Glez-Vaz, Belen Palencia, Ignacio Melero
来源：
Experimental Hematology & Oncology
摘要：
CD137 (4-1BB) 共刺激可有效激活抗肿瘤 T 淋巴细胞，并引发与抗 PD(L)1 检查点抑制剂协同的抗肿瘤功效，尤其是在使用双特异性构建体时。新出现的实验证据表明，4-1BB 连接可以防止并可能恢复 T 细胞耗竭。请参阅 Jeon 等人的相关文章，第 17 页。 XX.©2024 美国癌症研究协会。
CD137 (4-1BB) costimulation results in the potent activation of antitumor T lymphocytes and elicits antitumor efficacy that is synergistic with anti-PD(L)1 checkpoint inhibitors, especially when using bispecific constructs. Emerging experimental evidence indicates that 4-1BB ligation prevents and may revert T-cell exhaustion. See related article by Jeon et al., p. XX.©2024 American Association for Cancer Research.