分泌组由间充质干细胞（MSC）释放的生物活性化学物质组成，在再生医学中具有治疗前景。本综述旨在探讨 MSC 分泌组在再生泌尿外科中的治疗潜力，特别是治疗勃起功能障碍 (ED)，并概述 MSC 在 ED 治疗中的临床前和临床研究，并随后强调其基本原理、机制、临床前研究。 MSC 分泌组在这方面的研究和治疗潜力。该综述纳入了涉及 MSC 治疗 ED 的临床前和临床研究的分析。随后，它深入研究了有关间充质干细胞分泌蛋白组的现有知识，探索其治疗潜力。这些方法包括对相关文献的全面检查，以了解 MSC 分泌组治疗功效的潜在过程。临床前研究表明 MSC 分泌组在治疗各种 ED 模型中的有效性。然而，其治疗功效的确切机制仍不清楚。该综述提供了对 MSC 分泌组的抗炎、促血管生成和营养特性的见解。它还讨论了潜在的优势，例如避免与细胞治疗相关的问题，包括免疫原性、肿瘤转化和成本。这篇综述强调了 MSC 分泌组在再生泌尿学中的显着治疗潜力，特别是对于 ED 治疗。虽然临床前研究显示出有希望的结果，但在临床应用之前，进一步的研究对于阐明治疗功效背后的具体机制至关重要。该综述最后讨论了未来的前景，并强调了再生泌尿学中 MSC 分泌蛋白组临床转化相关的挑战。© 2024 年亚洲泌尿学杂志编辑部。由 Elsevier B.V. 制作和主持

The secretome, comprising bioactive chemicals released by mesenchymal stem cells (MSCs), holds therapeutic promise in regenerative medicine. This review aimed to explore the therapeutic potential of the MSC secretome in regenerative urology, particularly for treating erectile dysfunction (ED), and to provide an overview of preclinical and clinical research on MSCs in ED treatment and subsequently to highlight the rationales, mechanisms, preclinical investigations, and therapeutic potential of the MSC secretome in this context.The review incorporated an analysis of preclinical and clinical research involving MSCs in the treatment of ED. Subsequently, it delved into the existing knowledge regarding the MSC secretome, exploring its therapeutic potential. The methods included a comprehensive examination of relevant literature to discern the processes underlying the therapeutic efficacy of the MSC secretome.Preclinical research indicated the effectiveness of the MSC secretome in treating various models of ED. However, the precise mechanisms of its therapeutic efficacy remain unknown. The review provided insights into the anti-inflammatory, pro-angiogenic, and trophic properties of the MSC secretome. It also discussed potential advantages, such as avoiding issues related to cellular therapy, including immunogenicity, neoplastic transformation, and cost.This review underscores the significant therapeutic potential of the MSC secretome in regenerative urology, particularly for ED treatment. While preclinical studies demonstrate promising outcomes, further research is essential to elucidate the specific mechanisms underlying the therapeutic efficacy before clinical application. The review concludes by discussing future perspectives and highlighting the challenges associated with the clinical translation of the MSC secretome in regenerative urology.© 2024 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.