尽管之前的研究表明吸烟与肺癌患者死亡率之间存在相关性，但早期生活因素对这种关系的影响仍不清楚，需要进一步研究。本研究旨在调查母乳喂养可降低肺癌相关死亡风险的假设。作者进行了一项前瞻性队列研究，涉及从英国生物银行招募的 501,859 名参与者，以探讨母乳喂养与肺癌死亡风险之间的潜在关联使用 Cox 比例风险模型。随后，计算了肺癌的多基因风险评分，以检测基因与环境之间的相互作用。在总共 501 859 名参与者的中位随访时间 11.8 年中，发现母乳喂养可以降低患肺癌的风险 -相关死亡以及母亲吸烟对成年后代肺癌死亡率的影响。这种关联在分层后保持一致。此外，在高遗传风险水平下，母亲吸烟和母乳喂养对肺癌死亡风险的影响显着。母乳喂养可以降低肺癌相关死亡的风险以及母亲吸烟对成年后代肺癌死亡率的影响。这种相关性有可能降低后代肺癌相关死亡的可能性。版权所有 © 2024 作者。由 Wolters Kluwer Health, Inc. 出版

Although previous research has indicated a correlation between smoking and the mortality rate in patients with lung cancer, the impact of early life factors on this relationship remains unclear and requires further investigation. This study aimed to investigate the hypothesis that breastfeeding reduces the risk of lung cancer-related death.The authors conducted a prospective cohort study involving 501 859 participants recruited from the United Kingdom Biobank to explore the potential association between breastfeeding and the risk of lung cancer mortality using a Cox proportional hazards model. Subsequently, the polygenic risk score for lung cancer was calculated to detect interactions between genes and the environment.Over a median follow-up duration of 11.8 years, encompassing a total of 501 859 participants, breastfeeding was found to reduce the risk of lung cancer-related death and the impact of maternal smoking on lung cancer mortality in adult offspring. This association remained consistent after stratification. Furthermore, the influence of maternal smoking and breastfeeding on the risk of lung cancer mortality was significant at a high genetic risk level.Breastfeeding can reduce the risk of lung cancer-related death and the impact of maternal smoking on lung cancer mortality in adult offspring. This correlation has the potential to reduce the probability of lung-cancer-related deaths in subsequent generations.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.