卡波西肉瘤 (KS) 是一种由人疱疹病毒 8 (HHV-8) 引起的血管增殖性疾病，由免疫缺陷环境中的细胞因子介导。本研究旨在比较患有播散性 KS (DKS) 的 AIDS 患者、未接受过治疗但不患有 DKS 的 HIV 感染者 (PLWHIV) 以及健康对照者的 IL-6、IL-10 和 TNFα 水平。次要结果是比较 DKS 患者的细胞因子水平和不良结果，以及分析细胞因子随时间的变化。这项队列研究在墨西哥城的两个中心进行。包括三组。第 1 组：未接受过 HIV 治疗但患有 DKS，第 2 组：未接受过 HIV 治疗但未接受过 KS，第 3 组：HIV 阴性、健康对照。在第 1 组和第 2 组中，在基线和一段时间内测量血浆 IL-6、IL-10 和 TNFα 水平。 纳入了 76 名患者：第 1 组 39 名 (52%)、第 2 组 17 名 (22%)、第 3 组有 20 名 (26%)。第 1 组中位基线 IL-6、IL-10 和 TNFα 水平显着较高。在第 1 组中，死亡患者的基线 IL-6 高于幸存者 (14.4 vs 5.8 pg/mL p=0.048）。因 KS 导致的严重免疫重建炎症综合征 (S-IRIS-KS) 患者的 IL-6 值高于无 KS 患者（14.4 vs 5.8 pg/mL，p=0.004）。在第 1 组的重复测量模型中，死亡患者 (p<0.001) 和发生 IRIS-KS (p=0.01) 的 IL-10 水平较高。IL-6、IL-10 和 TNF α 水平显着升高DKS 患者中更高。不良结果患者的 IL-6 和 IL-10 水平较高。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。

Kaposi sarcoma (KS) is an angioproliferative disease caused by human herpesvirus 8 (HHV-8) and is mediated by cytokines in an immunodeficient environment. This study aimed to compare IL-6, IL-10, and TNFα levels among AIDS patients with disseminated KS (DKS), treatment naïve patients living with HIV (PLWHIV) without DKS, and healthy controls. Secondary outcomes were to compare cytokines levels in patients with DKS and unfavorable outcomes, as well as an analysis of the behavior of cytokines over time.This cohort study was performed at two centers in Mexico City. Three groups were included. Group 1: HIV+ treatment naïve with DKS, Group 2: HIV+ treatment naïve without KS, and Group 3: HIV negative, healthy controls. Plasmatic IL-6, IL-10, and TNFα levels were measured at baseline and over time in Groups 1 and 2.Seventy-six patients were included: 39 (52%) in Group 1, 17 (22%) in Group 2, and 20 (26%) in Group 3. The median baseline IL-6, IL-10, and TNFα levels were significantly higher in group 1. In group 1, baseline IL-6 was higher in patients who died than in survivors (14.4 vs 5.8 pg/mL p=0.048). Patients with severe immune reconstitution inflammatory syndrome due to KS (S-IRIS-KS) had higher IL-6 values than those without it (14.4 vs 5.8 pg/mL p=0.004). In the repeated-measures model in group 1, IL-10 levels were higher in patients who died (p<0.001) and developed IRIS-KS (p=0.01).IL-6, IL-10, and TNF α levels were markedly higher in patients with DKS. IL-6 and IL-10 levels were higher in patients with unfavorable outcomes.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.