虚弱是一种与衰老相关的临床状况，会导致外源性或内源性应激源产生不良后果的风险增加。在肿瘤学中，癌症治疗本身可能是一种压力事件。因此，在老年癌症患者中，虚弱不仅增加了与年龄相关的健康事件（例如住院或跌倒）的可能性，而且还增加了治疗并发症（例如毒性和治疗中断或终止）的可能性。最近在接受系统治疗的老年癌症患者中进行的随机对照试验表明，通过老年评估（GA）评估衰弱程度，然后调整肿瘤治疗以及有针对性的衰弱干预措施有助于提高癌症治疗的耐受性和可行性。根据这些数据，美国临床肿瘤学会 (ASCO) 更新了评估和管理接受全身癌症治疗的老年人脆弱性的临床实践指南。该指南建议使用一种名为“实用老年评估”(PGA) 的新 GA 工具，以促进在常规癌症护理中实施基于 GA 的衰弱评估和管理。本文介绍了这些最新进展的背景和关键方面。Thieme。版权所有。

Frailty is a clinical condition associated with aging and resulting in increased risk of adverse outcomes upon exogenous or endogenous stressors. In oncology, cancer treatment itself can be a stressor event. In older cancer patients, frailty therefore not only enhances the probability of age-related health events such as institutionalization or falls, but also of treatment complications such as toxicity and interruption or discontinuation of therapy. As demonstrated by recent randomized-controlled trials conducted in older cancer patients receiving systemic treatment, the evaluation of frailty by geriatric assessment (GA) followed by an adjustment of the oncological therapy as well as targeted frailty interventions help to improve cancer treatment tolerability and feasibility. Based on these data, the American Society of Clinical Oncology (ASCO) updated the clinical practice guidelines for the assessment and management of vulnerabilities in older adults receiving systemic cancer therapy. The guideline recommends the use of a new GA-tool named 'practical geriatric assessment' (PGA) to foster the implementation of GA-based frailty assessment and management in routine cancer care. This article describes the background and key aspects of these recent advances.Thieme. All rights reserved.