肺癌对人类健康造成重大威胁。尽管近年来治疗技术取得了相当大的进步，但肺癌患者的五年生存率仍然很低。在此背景下，细胞焦亡这种独特的细胞死亡机制的发现，为探索肺癌治疗新途径提供了新的视角。特别是gasdermin E (GSDME)在细胞焦亡过程中的作用揭示了其在肺癌治疗中的巨大潜力。最近的研究在理解 GSDME 介导的细胞焦亡在肺癌生长中的作用、肺癌微环境以及 GSDME 甲基化对肺癌治疗的影响方面取得了相当大的进展。本文总结了这些研究进展，并分析了GSDME介导的细胞焦亡在肺癌治疗中的潜在和可能的副作用，旨在为制定更有效的肺癌治疗策略提供理论基础。
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Lung cancer causes a significant threat to human health. Despite considerable advancements in the treatment technologies in recent years, the five-year survival rate for lung cancer patients remains low. In this context, the discovery of pyroptosis, a unique cell death mechanism, offers a novel perspective for exploring new pathways of lung cancer treatment. Particularly, the role of gasdermin E (GSDME) in the process of pyroptosis reveals its tremendous potential in lung cancer therapy. Recent studies have made considerable progress in understanding the role of GSDME-mediated pyroptosis in lung cancer growth, the lung cancer microenvironment, and the effect of GSDME methylation on lung cancer treatment. This paper summarizes these research advancements and analyzes the potential and possible side effects of GSDME-mediated pyroptosis in lung cancer therapy, aiming to provide a theoretical foundation for developing more effective strategies for lung cancer treatment.
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