人参是一种珍贵的药用资源，可用于治疗多种疾病。皂苷是最重要的生物活性成分，而稀有人参皂苷（Rg3、Rh2、Rk1和Rg5等）是指初级人参皂苷通过脱水、脱糖反应发生化学结构变化，得到更容易被人体吸收的三萜类化合物。目前，对人参的研究较多。广泛关注于抗癌相关方面，而对稀有人参皂苷的抗菌和皮肤保护作用的研究较少。该综述总结了与细菌抑制和皮肤保护相关的稀有人参皂苷，为人参研究提供了新的方向。检索了PubMed和Web of Science 2002年1月至2024年3月发表的关于人参的英文研究。 选稿手动评估以获取其他相关参考。本综述包括基础科学文章和前瞻性、回顾性队列研究等相关研究。本文总结了几种稀有人参皂苷的最新研究进展，讨论了稀有人参皂苷的抗菌作用，发现人参皂苷可以有效保护皮肤、促进伤口愈合在使用过程中，从而发挥高效的抗菌作用，进一步发掘人参的其他药用价值。预计本次综述将为人参药物的进一步研究和开发提供更广泛的认识和新思路。版权所有©2024。由Elsevier GmbH出版。

Panax ginseng C. A. Mey is a precious medicinal resource that could be used to treat a variety of diseases. Saponins are the most important bioactive components of, and rare ginsenosides (Rg3, Rh2, Rk1 and Rg5, etc.) refer to the chemical structure changes of primary ginsenosides through dehydration and desugarization reactions, to obtain triterpenoids that are easier to be absorbed by the human body and have higher activity.At present, the research of P. ginseng. is widely focused on anticancer related aspects, and there are few studies on the antibacterial and skin protection effects of rare ginsenosides. This review summarizes the rare ginsenosides related to bacterial inhibition and skin protection and provides a new direction for P. ginseng research.PubMed and Web of Science were searched for English-language studies on P. ginseng published between January 2002 and March 2024. Selected manuscripts were evaluated manually for additional relevant references. This review includes basic scientific articles and related studies such as prospective and retrospective cohort studies.This paper summarizes the latest research progress of several rare ginsenosides, discusses the antibacterial effect of rare ginsenosides, and finds that ginsenosides can effectively protect the skin and promote wound healing during use, so as to play an efficient antibacterial effect, and further explore the other medicinal value of ginseng. It is expected that this review will provide a wider understanding and new ideas for further research and development of P. ginseng drugs.Copyright © 2024. Published by Elsevier GmbH.