据推测，双相情感障碍（BD）与加速生物衰老有关。端粒长度 (TL) 是衰老的生物标志物，虽然 TL 随着每次细胞分裂而减少，但端粒缩短的速度可能会受到炎症的影响。我们旨在调查 BD 患者的 TL 是否降低，并确定此类患者的 TL 与炎症标志物之间的关联。招募了 137 名 BD 患者和 118 名健康对照 (HC)。白细胞 TL 和血浆细胞因子水平 [肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-8、IL-6、IL-10、转化生长因子 (TGF)-β1]、C 反应蛋白 (CRP)、并评估了脑源性神经营养因子（BDNF）。调整潜在混杂因素后，BD 患者和 HC 之间的 TL 没有显着差异（P=0.79）。 TL与年龄显着负相关（β=-0.006，P<0.001）。此外，在 BD 患者 (P=0.02) 和 HC 患者 (P=0.05) 中，log TNF-α 水平与 TL 显着负相关 (P=0.009)。我们发现 TNF-α 水平与 TL 之间存在显着相关性BD 患者和 HC 均缩短。然而，与 HC 相比，BD 患者并未表现出 TL 缩短增加。需要进行涉及更大样本量并控制 BD 参与者异质性的研究。版权所有 © 2024。由 Elsevier B.V. 出版。

Bipolar disorder (BD) is hypothesized to be associated with accelerated biological aging. Telomere length (TL) is a biomarker of aging, and although TL decreases with each cell division, the rate of telomere shortening may be affected by inflammation. We aimed to investigate whether TL is decreased in BD patients and to determine the association between TL and inflammatory markers in such patients.137 BD patients and 118 healthy controls (HCs) were recruited. Leukocyte TL and plasma levels of cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-8, IL-6, IL-10, transforming growth factor (TGF)-β1], C-reactive protein (CRP), and brain-derived neurotrophic factor (BDNF) were assessed.TL did not differ significantly between the BD patients and HCs after adjustment for potential confounding factors (P = 0.79). TL was significantly negatively associated with age (β = -0.006, P < 0.001). In addition, log TNF-α levels were significantly negatively associated with TL (P = 0.009), in both the BD patients (P = 0.02) and HCs (P = 0.05).We found a significant association between TNF-α levels and TL shortening in both BD patients and HCs. However, BD patients did not display increased TL shortening relative to HCs. Studies that involve larger sample sizes and control for the heterogeneity of BD participants will be needed.Copyright © 2024. Published by Elsevier B.V.