前列腺癌位列全球六种最致命的恶性肿瘤之一。端粒酶是一种逆转录酶，在延长细胞端粒方面发挥着关键作用，并与细胞增殖和分裂密切相关。然而，前列腺癌与端粒酶相关基因（TEASE）之间的相互关系仍不清楚。对TEASE的体细胞突变和拷贝数改变进行了全面分析。随后，TCGA 和 GEO 数据库中前列腺癌患者的转录本被整合以描述新的分子亚型。然后通过不同亚型之间的Lasso回归和Cox预后分析构建了包含9个特征基因的风险模型。比较了不同风险组之间的预后、肿瘤微环境（TME）、免疫格局、肿瘤突变负荷（TMB）、干细胞相关性和中位抑制浓度等各个方面。最后，探讨了ZW10相互作用蛋白（ZWINT）的体外表达、预后和恶性生物学行为。TEASEs表现出显着高的突变频率。描述了基于 TEASE 的三种不同的分子亚型和两个基因亚群，显示出与预后、免疫功能调节和临床特征的显着相关性。低风险患者表现出良好的预后和对免疫治疗的更好的反应。相反，高风险患者表现出更高的 TMB 和更强的干细胞相关性。研究还发现，患者对化疗药物的敏感性受到风险评分的影响。最后，ZWINT 作为前列腺癌新型诊断和预后生物标志物的潜力得到了验证。TEASE 在调节免疫调节和免疫治疗反应中发挥着关键作用，从而显着影响受影响患者的诊断、预后和治疗策略。© 2024。作者（s）。

Prostate cancer ranks among the six most lethal malignancies worldwide. Telomerase, a reverse transcriptase enzyme, plays a pivotal role in extending cellular telomeres and is intimately associated with cell proliferation and division. However, the interconnection between prostate cancer and telomerase-related genes (TEASEs) remains unclear.Somatic mutations and copy number alterations of TEASEs were comprehensively analyzed. Subsequently, the transcripts of prostate cancer patients in TCGA and GEO databases were integrated to delineate new molecular subtypes. Followed by constructing a risk model containing nine characteristic genes through Lasso regression and Cox prognostic analysis among different subtypes. Various aspects including prognosis, tumor microenvironment (TME), landscape of immunity, tumor mutational burden (TMB), stem cell correlation, and median inhibitory concentration amongst different risk groups were compared. Finally, the expression, prognosis, and malignant biological behavior of ZW10 interactor (ZWINT) in vitro was explored.TEASEs exhibited a notably high mutation frequency. Three distinct molecular subtypes and two gene subclusters based on TEASEs were delineated, displaying significant associations with prognosis, immune function regulation, and clinical characteristics. Low-risk patients demonstrated superior prognosis and better response to immunotherapy. Conversely, high-risk patients exhibited higher TMB and stronger stem cell correlations. It was also found that the patients' sensitivity to chemotherapy agents was impacted by the risk score. Finally, ZWINT's potential as a novel diagnostic and prognostic biomarker for prostate cancer was validated.TEASEs play a pivotal role in modulating immune regulation and immunotherapeutic responses, thereby significantly impacting the diagnosis, prognosis, and treatment strategies for affected patients.© 2024. The Author(s).