许多植物来源的生物活性化合物在预防慢性疾病方面显示出巨大的前景，其中类黄酮构成了一类天然存在的多酚化合物。芹菜素是一种被称为 4',5,7-三羟基黄酮的黄酮，作为慢性疾病的预防剂具有巨大的前景。尽管其广泛的研究和公认的营养保健价值，但其治疗应用仍未得到充分探索，需要进一步的临床研究。这篇综述深入探讨了芹菜素的生物来源、营养保健前景、化学、药理学见解和健康益处。通过多方面的分析研究，我们探索其多样化的药理学特征和在各个健康领域的潜在治疗应用。该手稿全面研究了芹菜素作为神经保护、抗炎化合物和有效抗氧化剂的作用。此外，还讨论了其对抗心血管疾病、抗糖尿病特性和抗癌潜力的功效。此外，抗菌特性和围绕其生物利用度的挑战，特别是草药补充剂的挑战已经得到解决。有多种形式可供选择，包括片剂、胶囊、固体分散体、共晶、包合物和纳米制剂。此外，它还作为草药配方中的营养补充剂而流行。尽管在克服药代动力学障碍方面已经取得了长足的进步，但为了使其在预防医学中得到广泛应用，对芹菜素的临床有效性和草药补充剂的生物利用度进行进一步研究仍然是当务之急。

A multitude of plant-derived bioactive compounds have shown significant promise in preventing chronic illnesses, with flavonoids constituting a substantial class of naturally occurring polyphenolic compounds. Apigenin, a flavone identified as 4',5,7-trihydroxyflavone, holds immense promise as a preventative agent against chronic illnesses. Despite its extensive research and recognized nutraceutical value, its therapeutic application remains underexplored, necessitating further clinical investigations. This review delves into the biological sources, nutraceutical prospects, chemistry, pharmacological insights, and health benefits of apigenin. Through multifaceted analytical studies, we explore its diverse pharmacological profile and potential therapeutic applications across various health domains. The manuscript comprehensively examines apigenin's role as a neuroprotective , anti-inflammatory compound, and a potent antioxidant agent. Additionally, its efficacy in combating cardiovascular diseases, anti-diabetic properties, and anticancer potential has been discussed. Furthermore, the antimicrobial attributes and the challenges surrounding its bioavailability, particularly from herbal supplements have been addressed. Available in diverse forms including tablets, capsules, solid dispersions, co-crystals, inclusion complexes and nano formulations. Additionally, it is prevalent as a nutraceutical supplement in herbal formulations. While strides have been made in overcoming pharmacokinetic hurdles, further research into apigenin's clinical effectiveness and bioavailability from herbal supplements remains imperative for its widespread utilization in preventive medicine.