这项综合综述旨在强调研究 AHCYL1（也称为 IRBIT）在癌细胞中的功能作用的重要性。最近有人提出，AHCYL1 调节细胞存活/死亡、干细胞能力以及宿主对肿瘤微环境的适应性反应。尽管有了这些知识，AHCYL1 在癌症中的作用仍然存在争议，可能是因为它能够以组织特异性方式与多种因素相互作用。了解肿瘤与控制 AHCYL1 表达的肿瘤微环境之间功能相互作用的调节机制可以提供对肿瘤发展调节的更深入的理解。解决 AHCYL1 如何在肿瘤环境中调节细胞可塑性过程可能与开发癌症生物学转化方法相关。版权所有 © 2024。由 Elsevier B.V. 出版。

This integrative review aims to highlight the importance of investigating the functional role of AHCYL1, also known as IRBIT, in cancer cells. It has recently been suggested that AHCYL1 regulates cell survival/death, stemness capacity, and the host adaptive response to the tumor microenvironment. Despite this knowledge, the role of AHCYL1 in cancer is still controversial, probably due to its ability to interact with multiple factors in a tissue-specific manner. Understanding the mechanisms regulating the functional interplay between the tumor and the tumor microenvironment that controls the expression of AHCYL1 could provide a deeper comprehension of the regulation of tumor development. Addressing how AHCYL1 modulates cellular plasticity processes in a tumoral context is potentially relevant to developing translational approaches in cancer biology.Copyright © 2024. Published by Elsevier B.V.