胃癌是一个健康问题，并导致与癌症相关的死亡。胃肠化生（GIM）是胃癌的癌前病变。目前，与 GIM 回归相关的因素尚未得到充分研究。本研究旨在评估 GIM 消退率并确定与其相关的因素。本研究在 Medstar 华盛顿医院中心进行。我们纳入了 2015 年 1 月至 2020 年 12 月期间患有 GIM 的患者。人群分为 GIM 持续期或消退期。数据包括人口统计、食管胃十二指肠镜检查结果、幽门螺杆菌状况和实验室结果。统计分析包括 Kaplan-Meier 和 Cox 比例模型，以探索 GIM 回归的预测因素。在 2375 名患者中，9.1% 患有 GIM。值得注意的是，85 名患者出现 GIM 消退，132 名患者出现持续性 GIM。非裔美国人构成回归组（75%）和坚持组（76%）。回归组中，基线时有 12.9% 的人患有消化性溃疡 (PUD)，随访时这一比例为 5.9%；坚持组基线时为 11.4%，随访时为 5.3%（P = 0.89）。回归分析显示，PUD 的存在与较高的回归率相关（风险比 [HR] 2.46，P = 0.013）。吸烟状况显示回归率较低（HR 0.54 和 0.62，P = 0.038 和 0.169）。在胃图上，非裔美国人、西班牙裔和其他种族/族裔的个体显示出较低的 GIM 回归率（HR 0.68、0.78 和 0.69）。PUD 与较高的 GIM 回归率相关，而吸烟则表现出较低的回归率。结果提供了对影响非裔美国人群体 GIM 消退的因素的见解，并可能为未来的监测和治疗策略提供信息。© 2024 作者。 JGH Open 由 Journal of Gastroenterology and Hepatology Foundation 和 John Wiley 出版

Gastric cancer is a health concern and contributes to cancer-related deaths. Gastric intestinal metaplasia (GIM) is a premalignant lesion of gastric cancer. Currently, factors associated with GIM regression are under-investigated. This study aims to assess the rate of GIM regression and identify factors associated with it.This study was conducted at Medstar Washington Hospital Center. We included patients who had GIM between January 2015 and December 2020. Population was divided into GIM persistence or regression. Data included demographics, esophagogastroduodenoscopy findings, Helicobacter pylori status, and laboratory results. Statistical analyses included Kaplan-Meier and Cox proportional models to explore predictors of GIM regression.Among 2375 patients, 9.1% had GIM. Notably, 85 patients had GIM regression and 132 patients had persistent GIM. African Americans constituted (75%) of the regression group and (76%) of the persistence group. Peptic ulcer disease (PUD) was noted in 12.9% of the regression group at baseline, and 5.9% at follow-up; the persistence group showed 11.4% at baseline and 5.3% at follow-up (P = 0.89). Regression analysis revealed that the presence of PUD was associated with a higher rate of regression (hazard ratio [HR] 2.46, P = 0.013). Smoking status showed lower rates of regression (HR 0.54 and 0.62, P = 0.038 and 0.169). On gastric mapping, African Americans, Hispanics, and individuals of other races/ethnicities displayed lower rates of GIM regression (HR 0.68, 0.78 and 0.69).PUD was associated with a higher rate of GIM regression, while smoking showed lower regression rates. Results provide insights into factors influencing GIM regression in African American population and may inform future surveillance and treatment strategies.© 2024 The Author(s). JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.