在大型动物物种中，下颌骨的肿瘤过程及其治疗很少有报道。具体来说，骨巨细胞瘤在动物中是一种罕见的肿瘤，在人类中与局部侵袭行为和高复发率有关。整块切除是首选治疗方法，但根据肿瘤的位置，这可能会导致功能缺陷。本报告详细介绍了涉及山羊下颌骨和下颌联合的骨巨细胞瘤的诊断检查、治疗和长期结果。进行了广泛的下颌头侧切除术，涉及整个下颌联合，无需手术固定半下颌骨。肿瘤的组织学和电子显微镜检查结果与骨巨细胞瘤一致。尽管H3F3A基因突变被认为是人类巨细胞肿瘤发展的驱动因素，但通过分子分析，在本例中无法证实这种基因突变。后续检查显示双侧下颌骨自发二次融合，并且没有肿瘤复发的迹象。手术后近 1 年，业主报告没有肿瘤再生的迹象。版权所有 © 2024 Biermann、Piechl、Dinhopl、Fuchs-Baumgartinger、Weissenbacher-Lang 和 Bertram。

Neoplastic processes of the mandible and their treatment are rarely reported in large animal species. Specifically, giant cell tumor of bone is an uncommon tumor in animals and has been associated in humans with locally invasive behavior and a high recurrence rate. En-bloc resection is the treatment of choice, but depending on the localization of the tumor, this may result in functional deficits. This report details the diagnostic work-up, treatment, and long-term outcome of a giant cell tumor of bone involving the rostral mandible and mandibular symphysis of a goat. Extensive rostral mandibulectomy involving the entire mandibular symphysis without surgical fixation of the hemimandibles was performed. Histological and electron microscopic findings of the tumor were consistent with a giant cell tumor of bone. Although a mutation of the H3F3A gene is considered the driver of tumor development in human giant cell tumors, using molecular analysis, this gene mutation could not be confirmed in this case. Follow-up examinations revealed spontaneous secondary fusion of both hemimandibles and no signs of tumor recurrence. Nearly 1 year after surgery, the owners reported no signs of tumor regrowth.Copyright © 2024 Biermann, Piechl, Dinhopl, Fuchs-Baumgartinger, Weissenbacher-Lang and Bertram.