本研究的目的是将皮肤镜检查、超声检查 (US) 和最常见类型皮肤黑色素瘤 (CM) 的组织学中描述的诊断标准关联起来。我们进行了一项前瞻性研究，包括 40 例 CM 病例，通过皮肤镜检查对这些病例进行了分析Delta 30 皮肤镜和 Vidix 4.0 视频皮肤镜，使用高分辨率 20 MHz 线性探头进行超声（美国）检查，并进行组织病理学分析。该研究涉及 40 名经组织病理学证实的 CM 患者，其中 10 例为结节性黑色素瘤 (NM)，21 例为浅表扩散黑色素瘤（SSM）和九种原位黑色素瘤（MIS）。 US 测量的肿瘤厚度与组织病理学 Breslow 指数 (BI) 具有很强的相关性，特别是在 NM 和 SSM 组中。在组织病理学和超声检查中观察到溃疡的存在之间存在显着的相关性。皮肤镜分析揭示了特定特征与 CM 类型之间的显着关联。例如，非典型网络、不规则小球、不规则点、突出的皮肤边缘、有角度的线/多边形、点状和短线性血管以及与中位BI≤0.5mm相关的负网络的存在。相反，蓝白色纱、非典型血管、蓝黑色和乳红色的存在与中位 BI ≥ 2.3 mm 相关。此外，组织病理学中观察到的回归与皮肤镜检查中确定的回归相关，我们还发现超声中克拉克水平高的血管化的存在与皮肤镜检查中明显的皮肤标记的存在之间存在统计相关性。组织病理学消退的存在更频繁地与具有精确边缘、缺乏血管化的肿瘤以及与超声上没有溃疡的肿瘤相关。高有丝分裂率与肿瘤边缘不精确、血管化增加和超声可检测到的溃疡有关。使用皮肤镜和超声等非侵入性方法的创新 CM 诊断可以通过评估病变特征来提高准确性和治疗指导。版权所有 © 2024 Negrutiu, Danescu,波帕、罗戈扬、维萨和拜坎。

The aim of this study is to correlate the diagnostic criteria described in dermoscopy, ultrasonography (US), and histology of the most common types of cutaneous melanoma (CM).We conducted a prospective study including 40 CM cases, which were analyzed by dermoscopy using the Delta 30 dermatoscope and Vidix 4.0 videodermoscope, by ultrasound (US) using a high-resolution 20 MHz linear probe, along with histopathological analysis.The study involved 40 patients with histopathologically confirmed CM, comprising 10 nodular melanomas (NM), 21 superficial spreading melanomas (SSM), and nine in situ melanomas (MIS). US measurements of tumor thickness exhibited strong correlations with the histopathological Breslow index (BI), particularly in the NM and SSM groups. A notable correlation was observed between the presence of ulceration in histopathology and ultrasonography. Dermoscopic analysis revealed significant associations between specific features and CM types. For instance, the presence of an atypical network, irregular globules, irregular dots, prominent skin margins, angulated lines/polygons, dotted and short linear vessels, and negative network correlated with a median BI ≤ 0.5 mm. Conversely, the presence of blue-white veil, atypical vessels, blue-black color, and milky red color were associated with a median BI ≥ 2.3 mm. Furthermore, regression observed in histopathology correlated with regression identified in dermoscopy, we also found statistical correlations between the presence of vascularization at US with the high Clark level, and the presence of prominent skin markings at dermoscopy. The presence of histopathological regression was more frequently associated with tumors that had precise margins, absent vascularization and with those that did not have ulceration on US. The high mitotic rate was associated with tumors that presented imprecise margins, increased vascularization and US detectable ulceration.Innovative CM diagnosis using non-invasive methods like dermoscopy and ultrasound may enhance accuracy and treatment guidance by assessing lesion characteristics.Copyright © 2024 Negrutiu, Danescu, Popa, Rogojan, Vesa and Baican.