BPV-2 感染可引起牛的膀胱感染，当与食用蕨菜相关时，可进展为癌性膀胱肿瘤，也可表现为牛地方性血尿 (BEH)。本研究旨在评估牛血液和尿液中长期自然 BPV-2 感染（不包括食用蕨菜）。对 13 头没有蕨类植物接触史、受吉罗兰多乳头状瘤病影响的牛进行了 20 个月的监测。收集血液、尿液和疣样本用于 BPV-2 检测和临床实验室分析。所有动物的乳头状瘤和血液中均检测到 BPV-2，92.85% 的动物尿液中检测到 BPV-2，表明病毒在尿道中传播。尽管所有动物都感染了 BPV-2，但在研究期间没有一只动物表现出 BEH 迹象。因此，观察到仅 BPV-2 感染在 20 个月内不会诱发 BEH，这意味着与环境因素或遗传易感性之间存在复杂的相互作用。这强调了食用蕨菜在膀胱癌发生中的关键作用。该研究强调了 BEH 发病机制的复杂性，提倡纵向研究以充分理解 BPV-2 的作用。© 2024。作者获得 Springer Nature B.V. 的独家许可。

BPV-2 infection can cause bladder infections in cattle that, when associated with bracken fern consumption, can progress to cancerous bladder tumors and also present as bovine enzootic hematuria (BEH). This study aimed to evaluate the prolonged natural BPV-2 infection in the blood and urine of cattle, excluding bracken fern consumption. Thirteen Girolando papillomatosis-affected cattle with no bracken fern contact history were monitored for 20 months. Blood, urine, and wart samples were collected for BPV-2 detection and clinical laboratory analyses. All animals showed the presence of BPV-2 in papillomas and blood, and 92.85% showed BPV-2 in urine, suggesting viral dissemination in the urinary tract. Despite all animals being infected with BPV-2, none showed BEH signs during the study. Thus, it was observed that BPV-2 infection alone didn't induce BEH over 20 months, implying a complex interaction with environmental factors or genetic predisposition. This underlines bracken fern consumption's critical role in urinary bladder carcinogenesis. The study underscores BEH's pathogenesis complexity, advocating longitudinal studies to comprehend BPV-2's role fully.© 2024. The Author(s), under exclusive licence to Springer Nature B.V.