分化型甲状腺癌（DTC）是一种进展快、预后差的甲状腺癌，有效的临床治疗对于保障患者的预后健康具有重要意义。因此，我们评估改良Miccoli甲状腺切除术对DTC患者应激反应和生活质量的影响，旨在为今后DTC治疗提供更全面的参考。本研究回顾性分析了2023年1月至2023年12月我院收治的100例DTC患者研究参与者被分为两组：研究组（n = 57）接受改良米科利甲状腺切除术，对照组（n = 43）接受常规开放甲状腺切除术。比较两个实验组的手术指标（切口长度、手术时间、术中出血量、清扫淋巴结数量）和术后指标（术后疼痛、引流量、住院时间）。此外，在手术前后评估应激反应相关指标和免疫功能。此外，还对两个实验组的术后生活质量进行了调查。与对照组相比，研究组的手术时间更长，但切口长度更小，术中出血更少，术后疼痛评分更低，引流量更少，住院时间更短组（p < 0.05）。此外，我们观察到与对照组相比，研究组术后应激反应减少，免疫功能更好，生活质量评分更高（p < 0.05）。改良Miccoli甲状腺切除术可以有效缓解DTC患者术后应激反应并促进他们的术后康复和生活质量。

Differentiated thyroid cancer (DTC) is a type of thyroid cancer with rapid progression and poor prognosis, and effective clinical treatment is of great significance in safeguarding the prognostic health of patients. Therefore, we assessed the effect of modified Miccoli's thyroidectomy on stress responses and quality of life in DTC patients, aiming to provide a more comprehensive reference for future DTC treatment.This study retrospectively analyzed 100 DTC patients admitted to our hospital from January 2023 to December 2023. Study participants were divided into two groups: The research group (n = 57) receiving modified Miccoli's thyroidectomy and the control group (n = 43) receiving routine open thyroidectomy. Surgical indexes (incision length, operative time, intraoperative bleeding, and the number of lymph nodes dissected) and post-operative indexes (post-operative pain, drainage volume, and hospitalization time) were comparatively assessed between the two experimental groups. Furthermore, stress response-associated indexes and immune function were evaluated before and after surgery. Additionally, the post-operative quality of life was investigated in both experimental groups.The research group showed higher operative time but smaller incision length, less intraoperative bleeding, lower post-operative pain scores, less drainage volume, and shorter hospitalization time than the control group (p < 0.05). Furthermore, we observed reduced post-operative stress responses, better immune function, and higher quality of life scores in the research group compared to the control group (p < 0.05).Modified Miccoli's thyroidectomy can effectively alleviate post-operative stress responses in DTC patients and promote their post-operative rehabilitation and quality of life.