铁死亡是一种铁依赖性细胞死亡形式，由细胞膜中过量的脂质过氧化引起。在过去的十年中，铁死亡在自身免疫性疾病、炎症、感染和癌症生物学中的生理和病理作用已被揭示。令人兴奋的是，在对其他形式的细胞死亡具有抵抗力的癌症中，癌细胞代谢可能会通过铁死亡来诱导死亡。铁死亡敏感性受到氧化应激、脂质代谢和铁代谢的调节，这些都受到肿瘤微环境（TME）的影响。尽管某些癌细胞类型已被证明能够适应这些应激源，但尚不清楚免疫细胞如何调节其对铁死亡的敏感性。在这篇综述中，我们讨论了不同免疫细胞亚群中铁死亡敏感性的机制、铁死亡如何影响免疫细胞浸润 TME，以及这些相互作用如何决定上皮间质转化 (EMT) 和转移。虽然人们非常关注在癌细胞中诱导铁死亡，但这些是铁死亡调节策略如何影响抗肿瘤免疫的重要考虑因素。从这个角度来看，我们还讨论了铁死亡领域一些有前景的免疫疗法，以及在特定免疫细胞群中靶向铁死亡相关的挑战。版权所有 © 2024 Lupica-Tondo、Arner、Mogilenko 和 Voss。

Ferroptosis is an iron-dependent form of cell death that results from excess lipid peroxidation in cellular membranes. Within the last decade, physiological and pathological roles for ferroptosis have been uncovered in autoimmune diseases, inflammatory conditions, infection, and cancer biology. Excitingly, cancer cell metabolism may be targeted to induce death by ferroptosis in cancers that are resistant to other forms of cell death. Ferroptosis sensitivity is regulated by oxidative stress, lipid metabolism, and iron metabolism, which are all influenced by the tumor microenvironment (TME). Whereas some cancer cell types have been shown to adapt to these stressors, it is not clear how immune cells regulate their sensitivities to ferroptosis. In this review, we discuss the mechanisms of ferroptosis sensitivity in different immune cell subsets, how ferroptosis influences which immune cells infiltrate the TME, and how these interactions can determine epithelial-to-mesenchymal transition (EMT) and metastasis. While much focus has been placed on inducing ferroptosis in cancer cells, these are important considerations for how ferroptosis-modulating strategies impact anti-tumor immunity. From this perspective, we also discuss some promising immunotherapies in the field of ferroptosis and the challenges associated with targeting ferroptosis in specific immune cell populations.Copyright © 2024 Lupica-Tondo, Arner, Mogilenko and Voss.