伐昔洛韦对体外激活的哺乳动物巨噬细胞的抗炎免疫调节活性。
Anti-Inflammatory Immunomodulatory Activity of Valacyclovir on the in Vitro Activated Mammalian Macrophages.
发表日期：2024 Aug
作者：
Esra Aydemir
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS
摘要：
阿昔洛韦，通常称为阿昔洛韦，是一种核苷类似物，在体外对人疱疹病毒 6 (HHV-6)、巨细胞病毒 (CMV)、水痘带状疱疹病毒 (VZV) 和单纯疱疹病毒 (HSV) 表现出抗病毒活性。伐昔洛韦是阿昔洛韦的氨基酸酯前药。我们检查了伐昔洛韦（也是一种抗病毒剂）对炎症的影响。在一定浓度范围的伐昔洛韦存在下，脂多糖 (LPS) 会激活哺乳动物巨噬细胞。采用肿瘤坏死因子-α (TNF-α)、白细胞介素 6 (IL-6)、粒细胞巨噬细胞集落刺激因子 (GM-CSF) 和 IL-12p40 酶联免疫吸附测定 (ELISA) 来测量生产水平我们的结果表明，伐昔洛韦对 LPS 激活的哺乳动物巨噬细胞具有抗炎活性。伐昔洛韦有潜力在临床环境中用作具有抗炎特性的抗病毒药物分子。未来的研究需要进一步证实其对不同免疫系统细胞类型的活性。
Aciclovir, often known as acyclovir, is a nucleoside analog that exhibits antiviral activity in vitro against human herpesvirus 6 (HHV-6), cytomegalovirus (CMV), varicella-zoster virus (VZV), and herpes simplex virus (HSV). Valacyclovir is an amino acid ester prodrug of acyclovir. We examined valacyclovir, which is also an anti-viral agent, for its effects on inflammation.Mammalian Macrophages were activated by lipopolysaccharide (LPS) in the presence of a concentration range of Valacyclovir. Tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-12p40 enzyme-linked immunosorbent assay (ELISA) was performed to measure the production levels of these pro-inflammatory cytokines.Our results suggest that Valacyclovir had anti-inflammatory activity on the LPS-activated mammalian macrophages.Valacyclovir has the potential to be utilized in the clinical setting as an anti-viral drug molecule with anti-inflammatory properties. Future studies are needed to further confirm its activities on different immune system cell types.