一些3-取代-4-氧代-咪唑烷-2-(1H)-硫酮衍生物作为抗癌药物的体外细胞毒性筛选。
In vitro cytotoxicity screening of some 3-substituted-4-oxo-imidazolidin-2-(1H)-thione derivatives as anticancer drug.
发表日期：2024
作者：
Ibrahim Mohey El-Deen, Elsayed H Eltamany, Nourhan M Ali
来源：
Cell Death & Disease
摘要：
目的：本研究旨在研究新系列 2-硫代乙二酸衍生物（7 和 9）对两种癌细胞系的体外抗肿瘤活性。 材料
Aim: This study aimed to investigate the in vitro antitumor activity of new series of 2-thiohydanotin derivatives (7 and 9) against two cancer cell lines.Materials & methods: A new series of 2-thioxoimidazolidine derivatives (3-9) were synthesized and investigated for its structure through spectral analysis and also tested against (HepG-2) and (HCT-116) cell line.Results: Among the synthesized compounds, compound 7 halted liver cancer cells at the G0/G1 phase and triggered apoptosis of liver cancer. Contrarily, compound 9 caused colon cancer cells to be arrested at the S phase and trigger apoptosis. Also, they had a good inhibitory effect on (Nrf2).Conclusion: Both compounds had attractive lead molecules for the creation of colon and liver cancer medications.