噻唑烷酮连接的 1,2,3-三唑与 (R)-香芹酮作为新的潜在抗癌剂。
Thiazolidinone-linked-1,2,3-triazoles with (R)-Carvone as new potential anticancer agents.
发表日期：2024
作者：
Ali Oubella, Manal A Alossaimi, Yassine Riadi, Mashooq Ahmad Bhat, Ahmed Hassan Bakheit, Mohamed Labd Taha, Aziz Auhmani, Hamid Morjani, Mohammed H Geesi, Moulay Youssef Ait Itto
来源：
Cell Death & Disease
摘要：
目的：本研究探讨新型噻唑烷酮-1,2,3-三唑杂合体对 HT-1080、A-549 和 MDA-MB-231 癌细胞系的细胞毒性和凋亡作用。方法
Aim: This study explores the cytotoxic and apoptotic effects of novel thiazolidinone-1,2,3-triazole hybrids on HT-1080, A-549, and MDA-MB-231 cancer cell lines.Methods & results: The synthesized compounds underwent comprehensive characterization (NMR and HRMS) to confirm their structures and purity. Subsequent anticancer activity screening across diverse cancer cell lines revealed promising antitumor potential notably, compounds 6f and 6g. Mechanistic investigations unveiled that compound 6f triggers apoptosis through the caspase-3/7 pathway. In terms of in silico studies, the compound 6f was identified as a potent inhibitor of caspase-3 and caspase-7.Conclusion: The present study underscores the therapeutic potential of thiazolidinone-1,2,3-triazole hybrids against certain cancer cells. These findings highlight a promising avenue for the development of cancer treatment strategies utilizing these (R)-Carvone-based derivatives.