目的 探讨环状RNA（circRNA）circ_0073585在急性髓系白血病（AML）患者骨髓中的表达水平、临床意义及功能。 检测106例初诊AML患者和38例对照者骨髓样本中circ_0073585的表达水平。通过实时定量PCR (RQ-PCR) 检测。比较两组差异并分析其临床意义。通过受试者工作特征曲线（ROC）评估circ_0073585表达对AML的诊断价值。将慢病毒过表达circ_0073585载体和空载体的THP-1细胞分为两组：circ_0073585-THP-1和NC-THP-1组。采用CCK-8法和流式细胞术研究circ_0073585对THP-1细胞增殖、存活、凋亡及药物敏感性的影响。与对照组相比，AML患者骨髓中circ_0073585的表达水平显着降低（ P < 0.001）。 circ_0073585高表达组和低表达组白细胞计数、血小板计数（P < 0.01）和染色体风险（P < 0.05）差异有统计学意义。与NC-THP-1细胞相比，circ_0073585-THP-1细胞增殖和活力减弱（P < 0.01），凋亡率增加（P < 0.01），对高三尖杉酯碱的敏感性增强（P < 0.05）和盐酸柔红霉素（P<0.001）升高。AML患者circ_0073585表达水平降低。 circ_0073585的过表达可以抑制白血病细胞的增殖和活力，促进细胞凋亡，增加白血病细胞对化疗药物的敏感性。

To investigate the expression level, clinical significance and function of circular RNAs (circRNAs) circ_0073585 in the bone marrow of patients with acute myeloid leukemia (AML).The expression levels of circ_0073585 in bone marrow samples of 106 newly diagnosed AML patients and 38 controls were detected by real-time quantitative PCR (RQ-PCR). The differences were compared between the two groups and their clinical significance was analyzed. The diagnostic value of circ_0073585 expression for AML was evaluated by receiver operating characteristic curve(ROC). THP-1 cells with lentivirus overexpressing circ_0073585 vector and empty vector were divided into two groups: circ_0073585-THP-1 and NC-THP-1 group. CCK-8 assay and flow cytometry were used to study the effects of circ_0073585 on THP-1 cell proliferation, survival, apoptosis and drug sensitivity.Compared with the controls, the expression level of circ_0073585 in the bone marrow of AML patients was significantly reduced (P < 0.001). There was a statistically significant difference between the high and low expression groups of circ_0073585 in the white blood cell count, platelet count (P < 0.01) and chromosome risk (P < 0.05). Compared with NC-THP-1 cells, the proliferation and viability of circ_0073585-THP-1 cells were weakened (P < 0.01), the apoptosis rate was increased (P < 0.01), and the sensitivity to homoharringtonine (P < 0.05) and daunorubicin hydrochloride (P < 0.001) was increased.The expression level of circ_0073585 is decreased in AML patients. Overexpression of circ_0073585 can inhibit the proliferation and viability of leukemic cells, promote apoptosis, and increase sensitivity of leukemia cells to chemotherapy drugs.