CDO1调控常见代谢性疾病的分子机制[J].
[Molecular mechanism of CDO1 regulating common metabolic diseases].
发表日期：2024 Aug 25
作者：
Qi Liu, Wen-Qing Shen
来源：
PHYSICAL THERAPY & REHABILITATION JOURNAL
摘要：
1 型半胱氨酸双加氧酶 (CDO1) 属于半胱氨酸双加氧酶 (CDO) 家族。 CDO1是半胱氨酸分解代谢和牛磺酸合成的关键酶。 CDO1 在肝脏、脂肪组织、胰腺、肾脏、肺、脑和小肠中高表达。 CDO1参与多种常见代谢疾病的病理生理调节，如脂代谢紊乱、胰岛素抵抗、肥胖、肿瘤/癌症、神经退行性疾病等。本文综述了近年来CDO1调控常见代谢性疾病分子机制的研究进展，旨在为CDO1靶向治疗胰岛素抵抗、肥胖、肿瘤/癌症、神经退行性疾病等提供新的理论和实践依据。
Cysteine dioxygenase type 1 (CDO1) belongs to the cysteine dioxygenase (CDO) family. CDO1 is the key enzyme in cysteine catabolism and taurine synthesis. CDO1 is highly expressed in liver, adipose tissue, pancreas, kidney, lung, brain and small intestine. CDO1 is involved in the pathophysiological regulation of various common metabolic diseases, such as lipid metabolism disorders, insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases. This article summarizes the research progress on the molecular mechanisms of CDO1 regulation of common metabolic diseases in recent years, aiming to provide new theoretical and practical basis for CDO1-targeted therapy for insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases.