红树林相关菌株的新次生代谢物。
New Secondary Metabolites of Mangrove-Associated Strains.
发表日期：2024 Aug 16
作者：
Yunxia Yu, Zimin Wang, Dingmi Xiong, Liman Zhou, Fandong Kong, Qi Wang
来源：
Marine Drugs
摘要：
红树林位于陆地和海洋领域之间的动态交界处，体现了充满活力的生物多样性，包括一系列植物、动物和微生物。红树林栖息地的这些微生物居民已成为抗菌药物和大量具有药用价值的化合物的关键资源，涵盖酶、抗肿瘤剂、杀虫剂、免疫抑制剂和免疫调节剂。这篇综述深入研究了从红树林相关微生物中分离出的新型次生代谢物的最新情况（根据发表时间，为 2021 年 1 月至 2024 年 5 月），分析了 41 种微生物菌株，这些菌株总共产生了 165 种不同的化合物。我们的目标是评估近年来红树林生态系统内微生物种群衍生的天然产物的生产力和潜力。值得注意的是，真菌是这些新型天然产物出现的杰出贡献者，强调了它们在这些独特环境中的生物勘探工作中的关键作用。
Positioned at the dynamic interface between terrestrial and marine realms, mangroves embody a vibrant tapestry of biodiversity, encompassing an array of plants, animals, and microorganisms. These microbial inhabitants of mangrove habitats have emerged as a pivotal resource for antimicrobials and a plethora of pharmaceutically valuable compounds, spanning enzymes, antineoplastic agents, pesticides, immunosuppressants, and immunomodulators. This review delves into the recent landscape (January 2021 to May 2024, according to the time of publication) of novel secondary metabolites isolated from mangrove-associated microorganisms, analyzing 41 microbial strains that collectively yielded 165 distinct compounds. Our objective is to assess the productivity and potential of natural products derived from microbial populations within mangrove ecosystems in recent times. Notably, fungi stand out as the preeminent contributors to the emergence of these novel natural products, underscoring their pivotal role in the bioprospecting endeavors within these unique environments.