核酸疗法的进展：结构、递送系统和癌症治疗的未来前景。
Advances in nucleic acid therapeutics: structures, delivery systems, and future perspectives in cancer treatment.
发表日期：2024 Aug 28
作者：
Leqi Zhang, Wenting Lou, Jianwei Wang
来源：
PHARMACOLOGY & THERAPEUTICS
摘要：
癌症已成为对人类健康的重大威胁。核酸疗法通过引入外源核酸片段来调控基因表达过程，为肿瘤缓解甚至治愈提供了新的可能性。它们的作用机制和高特异性显示出在癌症治疗中的巨大潜力。然而，核酸药物面临稳定性低、体内跨生理屏障能力有限等挑战。为了解决这些问题，已经开发了各种核酸递送载体来增强稳定性并促进核酸药物在体内的精确靶向递送。在这篇综述文章中，我们主要介绍了癌症治疗中常用的核酸药物的结构和原理，以及它们的细胞摄取和细胞内运输过程。我们重点介绍了核酸药物递送中常用的各种载体，重点介绍了它们近年来的研究进展和应用。此外，我们还提出了未来核酸药物及其载体的潜在趋势和前景。© 2024。作者。
Cancer has emerged as a significant threat to human health. Nucleic acid therapeutics regulate the gene expression process by introducing exogenous nucleic acid fragments, offering new possibilities for tumor remission and even cure. Their mechanism of action and high specificity demonstrate great potential in cancer treatment. However, nucleic acid drugs face challenges such as low stability and limited ability to cross physiological barriers in vivo. To address these issues, various nucleic acid delivery vectors have been developed to enhance the stability and facilitate precise targeted delivery of nucleic acid drugs within the body. In this review article, we primarily introduce the structures and principles of nucleic acid drugs commonly used in cancer therapy, as well as their cellular uptake and intracellular transportation processes. We focus on the various vectors commonly employed in nucleic acid drug delivery, highlighting their research progress and applications in recent years. Furthermore, we propose potential trends and prospects of nucleic acid drugs and their carriers in the future.© 2024. The Author(s).