对于患有局部晚期宫颈癌的女性，标准护理治疗是治愈性放化疗 (CRT)。骨髓（BM）剂量体积直方图（DVH）与急性血液毒性（HT）之间的关系最近一直存在争议。本研究的目的是评估当代患者队列中的 BM 剂量限制和 HT。回顾性探讨了 31 例接受调强放疗和同步化疗的宫颈癌（FIGO IIB-IVB 期）患者的放射治疗计划。对骨盆骨 (PB) 和股骨头 (FH) 进行轮廓绘制，并将 DVH 与白细胞 (WBC)、血红蛋白水平和血小板相关。将绝对血液水平与 FH 和 PB 的剂量体积进行比较，数据显示出显着相关性WBC 与 FH 的中位剂量以及 PB 的中位剂量 V30Gy、V40Gy 和 V50Gy 之间。发现贫血的毒性等级与PB的平均剂量、最大剂量和V5Gy之间存在相关性。计算每位患者所有三个血液水平的最高 HT 级别，发现 PB 的平均和中位剂量、V30Gy、V40Gy 和 V50Gy 存在显着相关性。结果表明，血液水平可能与关键骨的不同剂量学亚体积相关骨髓室对治疗结果和治疗相关毒性具有潜在影响。所提供的数据与之前关于骨盆骨亚体积剂量学暴露相关性的发现一致。© 2024。作者。

For women with locoregionally advanced cervical cancer, the standard of care treatment is the curatively intended chemoradiation therapy (CRT). A relationship between bone marrow (BM) dose-volume histograms (DVHs) and acute hematological toxicity (HT) has been debated recently. Aim of this study was the evaluation of BM dose constraints and HT in a contemporary patient cohort.Radiation treatment plans of 31 patients with cervical cancer (FIGO stage IIB-IVB) treated with intensity-modulated radiotherapy and simultaneous chemotherapy were explored retrospective. Pelvic bones (PB) and femoral heads (FH) were contoured and DVHs were correlated with white blood cells (WBC), hemoglobin levels and platelets.Comparing the absolute blood levels with the dose volumes of both FH and PB the data showed a significant correlation between WBC and the median dose of the FH and the median dose, V30Gy, V40Gy and V50Gy of the PB. A correlation between the toxicity grade of anemia and mean dose, maximum dose and V5Gy of the PB was found. Counting the highest grade of HT of all three blood levels of each patient, significant correlations were found for the mean and median dose, V30Gy, V40Gy and V50Gy of the PB.The results show that blood levels may correlate with distinct dosimetric subvolumes of critical bone marrow compartments with a potential impact on therapeutic outcome and treatment-related toxicity. The data presented are in line with the previous findings on the relevance of dosimetric exposure of pelvic bony subvolumes.© 2024. The Author(s).