儿童脑肿瘤幸存者可能会受到放射治疗的不利影响。这项横断面、大型队列研究检查了质子放射治疗 (PRT) 后 ≥3 年的儿科患者的晚期心理社会和执行功能影响。101 名儿科脑肿瘤幸存者的父母完成了儿童行为评估系统和儿童行为评级清单执行职能。将标准分数与公布的规范平均值进行比较，计算损伤率（T 分数 > 65），并检查人口和临床特征。PRT 的平均年龄为 8.12 岁，从 PRT 到评估的平均间隔为 6.05 年。一半为女性（49.5%），45.5%接受颅脊髓照射（CSI），58.4%被诊断患有幕下肿瘤。所有平均 T 分数均在正常范围内。与退缩、启动、工作记忆和计划/组织量表的正常值相比，平均 T 分数显着升高。工作记忆（24.8%）、启动（20.4%）、退出（18.1%）和计划/组织（17.0%）的损伤率明显较高。更大程度的戒断与 CSI 以及化疗和听力损失的诊断显着相关。多动、攻击性、行为问题和抑制量表的平均 T 分数显着低于正常值。没有发现社交技能或抑郁方面的重大问题。治疗间隔与任何量表均无关。尽管心理社会和执行功能在正常范围内，但平均而言，社交退缩和元认知执行功能（工作记忆、启动、计划/组织）是值得关注的领域。该人群需要有针对性的年度筛查以及积极主动的执行技能和社会干预措施。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Pediatric brain tumor survivors can experience detrimental effects from radiation treatment. This cross-sectional, large cohort study examined late psychosocial and executive functioning effects in pediatric patients treated ≥ 3 years after proton radiation therapy (PRT).Parents of 101 pediatric brain tumor survivors completed the Behavior Assessment System for Children and the Behavior Rating Inventory of Executive Function. Standard scores were compared to published normative means, rates of impairment (T-score > 65) were calculated, and demographic and clinical characteristics were examined.Mean age at PRT was 8.12 years and mean interval from PRT to assessment was 6.05 years. Half were female (49.5%), 45.5% received craniospinal irradiation (CSI), and 58.4% were diagnosed with infratentorial tumors. All mean T-scores were within normal range. Mean T-scores were significantly elevated compared to the norm on the withdrawal, initiate, working memory, and plan/organize scales. Rates of impairment were notably high in working memory (24.8%), initiate (20.4%), withdrawal (18.1%), and plan/organize (17.0%). Greater withdrawal was significantly associated with CSI and also with chemotherapy and diagnosis of hearing loss. Mean T-scores were significantly lower than the norm on the hyperactivity, aggression, conduct problems, and inhibition scales. No significant problems were identified with social skills or depression. Interval since treatment was not correlated with any scale.Although psychosocial and executive functioning was within the normal range, on average, social withdrawal and metacognitive executive functioning (working memory, initiating, planning/organizing) were areas of concern. Targeted yearly screening and proactive executive skill and social interventions are needed for this population.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.