MAGUK p55 亚家族成员 7 是膜棕榈酰化蛋白亚家族的一部分，是促进上皮细胞极性的重要接头，在多种癌症中具有越来越重要的意义，包括食管癌、透明细胞肾细胞癌、乳腺癌和胰腺导管腺癌。本文旨在利用癌症基因组图谱和基因型组织表达数据库确定 MAGUK p55 亚家族成员 7 在各种肿瘤类型中的作用。使用cBioPortal、GEPIA2、TIMER2、UALCAN、R、STRING和DAVID等各种软件和网络平台来获取和分析数据。值得注意的是，在大多数癌症中观察到 MAGUK p55 亚家族成员 7 的低表达。此外，MAGUK p55 亚家族成员 7 的低表达预示着癌症患者的不良预后。突变是 MAGUK p55 亚家族成员 7 中最常见的遗传改变类型，在各种癌症中磷酸化位点被确定为 S412 和 S490。此外，MAGUK p55 亚家族成员 7 的表达与癌症相关成纤维细胞和 CD8 T 细胞相关。基因富集分析表明 MAGUK p55 亚家族成员 7 通过 Rap1 信号通路影响癌症。本文阐明了 MAGUK p55 亚家族成员 7 在人类泛癌预后和免疫反应中的生物学意义。© 2024 作者。

MAGUK p55 subfamily member 7, a part of the membrane palmitoylated protein subfamily, is an essential adapter that promotes epithelial cell polarity and has increasing significance in multiple cancers, including esophageal cancer, clear cell renal cell carcinoma, breast cancer, and pancreatic ductal adenocarcinoma. This paper aims to determine the effect of the MAGUK p55 subfamily member 7 in various tumor types using The Cancer Genome Atlas and Genotype-Tissue Expression database. A variety of software and web platforms, such as cBioPortal, GEPIA2, TIMER2, UALCAN, R, STRING, and DAVID, were used to obtain and analyze data. Notably, low expression of MAGUK p55 subfamily member 7 was observed in most cancers. In addition, low expression of MAGUK p55 subfamily member 7 predicted poor prognoses in cancer patients. Mutation was the most frequent genetic alteration type in MAGUK p55 subfamily member 7, with the phosphorylation sites identified as S412 and S490 in various cancers. Furthermore, expression of MAGUK p55 subfamily member 7 was associated with cancer-related fibroblasts and CD8+ T cells. Gene enrichment analysis indicated that MAGUK p55 subfamily member 7 influences cancer through the Rap1 signaling pathway. This paper elucidates the biological significance of MAGUK p55 subfamily member 7 in human pan-cancer prognosis and immune response.© 2024 The Authors.