本研究旨在调查七种土耳其榛子 (Corylus avellana L.) 基因型的可食用和不可食用部分的抗癌紫杉烷谱。榛子是富含营养和抗氧化剂的健康食品之一。经常食用它可以降低患冠心病和癌症的风险。榛子被描述为一种产生紫杉烷的植物来源，紫杉烷广泛用于许多癌症。土耳其是榛子文化的故乡，拥有自己的品种。对土耳其榛子基因型不同部分的抗癌紫杉烷谱的研究对于从制药和食品工业的角度展示该植物的潜力和价值非常重要。在这项研究中，绿叶覆盖物（GLC）和硬壳（HS）（ Çakıldak、Sivri、Tombul、Palaz 和 Kalınkara 的去皮籽粒 (SK)、棕皮籽粒 (BS) 和棕皮籽粒 (BSK)（可食用部分）为标准，火腿和 Sivri Yağlı 为标准使用当地基因型。将每个基因型的五个部分研磨成粉末并消除到小于80目的尺寸。使用己烷和甲醇提取每个部分，进行 10-脱乙酰浆果赤霉素 III (10-DAB III)、浆果赤霉素 III (BAC III)、三尖杉宁碱和紫杉醇分析，一式三份。样品和标准品采用乙腈：水梯度法在 NOVA Spher 100 Phenyl-Hexyl C18 柱上高效液相色谱反相系统中进行分析，配备 228 nm 紫外检测器和 1.0 mL/min 流速。连续使用 Microsoft Office Excel, 2016 和方差分析 Jamovi Version 2.3 进行统计和数据分析。榛子部件在 10-DAB III 的最高含量方面彼此存在很大程度的差异（火腿 HS，9 ,15 μg/g)、BAC III (Kalınkara BSs, 7.24 μg/g)、三尖杉宁碱 (Sivri Yağlı BSs, 6.37 μg/g) 和紫杉​​醇 (Ham BSKs, 4.36 μg/g)。虽然 HS、BSK 和 BS 在所有分析的基因型中都富含紫杉烷，但 SK 和 GLC 的抗癌紫杉烷含量仍然有限。这是第一份揭示土耳其榛子紫杉烷含量差异的报告，包括之前未经测试的标准和当地基因型和他们的部分。基因型和榛子部位之间的显着差异预计将凸显食用含有 BS 的生土耳其榛子的健康益处及其作为功能性食品的可能性。这些结果为阐明土耳其榛子及其副产品的生物活性潜力提供了更多信息，并从抗癌角度为食品和制药行业提供了有前景的资源。版权所有© 2024 作者。由 Galenos 出版社代表土耳其药剂师协会出版。

This study aimed to investigate the anticancer taxane profiles of edible and non-edible parts of seven Turkish hazelnut (Corylus avellana L.) genotypes. Hazelnut is one of the healthy foods rich in nutrients and antioxidants. Its regular consumption is associated with a reduced risk of coronary heart disease and cancer. Hazelnut has been described as a plant source that produces taxanes which are widely used in many cancers. Türkiye is a homeland of hazelnut culture and has its own cultivars. Investigation of anticancer taxane profiles in different parts of Turkish hazelnut genotypes is important to show the potential and value of this plant from the perspective of the pharmaceutical and food industries.In this study, green leafy covers (GLCs) and hard shells (HSs) (non-edible parts), skinless kernels (SKs), brown-skins (BSs), and brown-skinned kernels (BSKs) (edible parts) of Çakıldak, Sivri, Tombul, Palaz, and Kalınkara as standard and Ham and Sivri Yağlı as local genotypes were used. The five parts of each genotype were ground to powder and eliminated to a size of less than 80 mesh. Each part was extracted using hexane and methanol for 10-deacetylbaccatin III (10-DAB III), baccatin III (BAC III), cephalomannine, and paclitaxel analyses in three replicates. Samples and standards were analyzed by acetonitrile: water gradient method on NOVA Spher 100 Phenyl-Hexyl C18 column inhigh-performance liquid chromatography reverse phase system with 228 nm ultraviolet detector and 1.0 mL/min flow rate. Microsoft Office Excel, 2016, and analysis of variance Jamovi Version 2.3 were used for statistical and data analysis, consecutively.Hazelnut parts differed to a very high degree from each other in terms of the highest amount of 10- DAB III (Ham HSs, 9,15 μg/g), BAC III (Kalınkara BSs, 7.24 μg/g), cephalomannine (Sivri Yağlı BSs, 6.37 μg/g), and paclitaxel (Ham BSKs, 4.36 μg/g) they contained. While HSs, BSKs, and BSs were rich in taxanes in all of the analyzed genotypes, SKs, and GLCs remain limited for anticancer taxanes.This is the first report that revealed the differences in taxane contents of Turkish hazelnuts including previously untested standard and local genotypes and their parts. Significant differences between genotype and hazelnut parts are expected to highlight the health benefits of consuming raw Turkish hazelnut with BSs and their possible use as a functional food. These results add more information to elucidate the bioactive potential of Turkish hazelnuts and their by-products and provide a promising resource for the food and pharmaceutical industry with an anticancer perspective.Copyright© 2024 The Author. Published by Galenos Publishing House on behalf of Turkish Pharmacists’ Association.