芦丁，通常被称为维生素 P，是一种天然黄酮类化合物，具有广泛的治疗潜力。芦丁在食用后会被肠道细菌代谢成不同的化合物，因此很少被吸收。高等植物有助于大量芦丁的合成，并且在许多水果和果皮中也可能发现芦丁，特别是柑橘类水果和浆果。本文重点介绍了关于芦丁及其纳米制剂的广谱治疗潜力的几项研究。检索了包括Springer、PubMed、Science Direct、Pubchem等在内的众多电子数据库，提取了证明芦丁对各种疾病有效的相关公开文献。回顾的文献表明，芦丁和相关黄酮类化合物具有多种保护人类的生理特性，植物和动物。抗氧化、抗炎、抗过敏、细胞保护、血管保护、抗癌、神经保护、心脏保护、抗菌、抗病毒、抗原虫、抗肿瘤、抗高血压、抗血小板、解痉和降血脂等活性。纳米技术已被用于使用新型药物递送载体来提高芦丁的生物利用度。该研究的结论是，与传统的芦丁递送相比，用于多种治疗方法的芦丁纳米制剂的开发有助于增强水溶性以及定制的药代动力学。然而，应该进行更多的研究来确认芦丁纳米制剂的生物利用度得到改善。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Rutin, often known as vitamin P, is a natural flavonoid compound, which offers a broad spectrum of therapeutic potentials. Rutin is metabolised to different compounds by the gut bacteria after consumption, therefore, very little is absorbed. Higher plants contribute to rutin synthesis in large quantities, and it may also be found in many fruits and fruity rinds, particularly citrus fruits and berries.The present paper highlights several studies conducted on rutin along with its nanoformulations regarding its broad spectrum of therapeutic potentials.Numerous electronic databases, including Springer, PubMed, Science Direct, Pubchem, etc. were searched to extract relevant published literature demonstrating rutin effectiveness in various ailments.The reviewed literature showed that rutin and related flavonoids possess a variety of physiological properties that protects human beings, plants and animals. Antioxidant, anti-inflammatory, anti-allergic, cytoprotective, vasoprotective, anticarcinogenic, neuroprotective, cardioprotective, antibacterial, antiviral, antiprotozoal, antitumor, anti-hypertensive antiplatelet, antispasmodic and hypolipidemic, activities. Nanotechnology has been implemented for the improvement of the bioavailability of rutin using novel drug-delivery carriers.The study concludes that the development of rutin nanoformulations for multiple therapeutic approaches contributes towards enhanced aqueous solubility as well as tailored pharmacokinetics compared to conventional delivery of rutin. However, more investigations should be conducted to confirm the improved bioavailability of the rutin nanoformulations.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.