Klotho 是一种抗衰老蛋白，在多种生物功能中发挥着至关重要的作用，例如调节钙和维生素 D 水平、预防慢性纤维化、作为抗氧化剂和抗炎剂、预防心血管和神经退行性疾病，以及发挥抗细胞凋亡、抗衰老作用。此外，它还有助于与糖尿病相关的代谢过程，并具有抗癌特性。这种蛋白质通常在肾脏、大脑、胰腺、甲状旁腺、卵巢和睾丸等器官中表达。最近的研究强调了它对人类生育能力的重要性。这篇叙述性综述深入了解了 Klotho 蛋白在男性和女性生育能力中的参与，以及它在未来管理人类不育症中的潜在作用。在这项研究中，对 1997 年 11 月至 2024 年 6 月期间跨多个数据库（包括 PUBMED、SCOPUS 和 Google Scholar）的文献进行了检索，重点关注 Klotho 蛋白。搜索使用的关键词包括“Klotho 蛋白的发现”、“Klotho 的生物学功能”、“Klotho 在女性生育能力中的作用”、“Klotho 和 PCOS”、“Klotho 和冷冻保存”以及“Klotho 在男性不育中的作用”。纳入标准包括全文原创或评论文章以及摘要，讨论 Klotho 蛋白在人类生育能力中的作用，并以英文发表在各种同行评审期刊上。排除标准涉及以英语以外的语言发表的文章。因此，由于其抗衰老特性，Klotho蛋白在男性和女性生育能力方面具有潜在的作用，在生殖医学方面具有广阔的前景。此外，它有潜力成为解决男性和女性不孕问题的宝贵资产。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Klotho, an anti-aging protein, plays a vital role in diverse biological functions, such as regulating calcium and vitamin D levels, preventing chronic fibrosis, acting as an antioxidant and anti-inflammatory agent, safeguarding against cardiovascular and neurodegenerative conditions, as well as exerting anti-apoptotic, anti-senescence effects. Additionally, it contributes to metabolic processes associated with diabetes and exhibits anti-cancer properties. This protein is commonly expressed in organs, such as kidneys, brain, pancreas, parathyroid glands, ovaries, and testes. Recent research has highlighted its significance in human fertility. This narrative review provides insight into the involvement of Klotho protein in male and female fertility, as well as its potential role in managing human infertility in the future. In this study, a search was conducted on literature spanning from November 1997 to June 2024 across multiple databases, including PUBMED, SCOPUS, and Google Scholar, focusing on Klotho proteins. The search utilized keywords, such as "discovery of Klotho proteins," "Biological functions of Klotho," "Klotho in female fertility," "Klotho and PCOS," "Klotho and cryopreservation," and "Klotho in male infertility." Inclusion criteria comprised full-length original or review articles, as well as abstracts, discussing the role of Klotho protein in human fertility, published in English in various peer-reviewed journals. Exclusion criteria involved articles published in languages other than English. Hence, due to its anti-aging characteristics, Klotho protein presents potential roles in male and female fertility and holds promising prospects for reproductive medicine. Further, it holds the potential to become a valuable asset in addressing infertility concerns for both males and females.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.