由于传统化疗药物缺乏特异性和选择性，疗效有限且副作用明显，因此新的策略对于改善癌症治疗结果至关重要。在这里，我们成功地设计了涂覆有沸石咪唑骨架-8 (ZIF-8) 的 Fe3O4 磁性纳米颗粒。由于 ZIF-8 的多孔性质，所得纳米复合材料 (Fe3O4@ZIF-8) 能够有效吸附大量阿霉素 (DOX)。当外部磁场引导时，载药纳米粒子 Fe3O4@ZIF-8/DOX 在 SW620 结肠癌小鼠的肿瘤部位表现出显着的积累。在肿瘤的酸性微环境中，ZIF-8 框架崩溃，释放 DOX 并有效诱导肿瘤细胞死亡，从而抑制癌症进展，同时不会引起不良副作用，多种体外和体内特征证实。与游离 DOX 相比，Fe3O4@ZIF-8/DOX 纳米粒子在结肠癌治疗中表现出优越的功效。我们的研究结果表明，Fe3O4@ZIF-8有望作为小分子药物吸附的载体，其铁磁特性提供药物靶向能力，从而在相同药物剂量下增强对肿瘤的治疗效果。 Fe3O4@ZIF-8 具有优异的生物相容性，在靶向癌症化疗中显示出作为药物载体的潜力。我们的工作表明，磁性靶向和酸响应性的结合为推进精准纳米医学中的靶向癌症治疗带来了巨大希望。

Due to the limited efficacy and evident side effects of traditional chemotherapy drugs attributed to their lack of specificity and selectivity, novel strategies are essential for improving cancer treatment outcomes. Here, we successfully engineered Fe3O4 magnetic nanoparticles coated with zeolitic imidazolate framework-8 (ZIF-8). The resulting nanocomposite (Fe3O4@ZIF-8) demonstrates efficient adsorption of a substantial amount of doxorubicin (DOX) due to the porous nature of ZIF-8. The drug-loaded nanoparticles, Fe3O4@ZIF-8/DOX, exhibit significant accumulation at the tumor site in SW620 colon-cancer-bearing mice when guided by an external magnetic field. Within the acidic microenvironment of the tumor, the ZIF-8 framework collapses, releasing DOX and effectively inducing tumor cell death, thereby inhibiting cancer progression while not causing undesired side effects, as confirmed by a variety of in vitro and in vivo characterizations. In comparison to free DOX, Fe3O4@ZIF-8/DOX nanoparticles show superior efficacy in colon cancer treatment. Our findings suggest that Fe3O4@ZIF-8 holds promise as a carrier for small-molecule drug adsorption and its ferromagnetic properties provide drug targeting capabilities, thereby enhancing therapeutic effects on tumors at the same drug dosage. With excellent biocompatibility, Fe3O4@ZIF-8 demonstrates potential as a drug carrier in targeted cancer chemotherapy. Our work suggests that a combination of magnetic targeting and acid-responsiveness holds great promise for advancing targeted cancer therapy in precision nanomedicine.