人乳头瘤病毒 (HPV) 是一种广泛传播的性传播病毒，会在某个阶段感染大多数人，导致尖锐湿疣和癌症。它们是乳头瘤病毒科的成员，该科包含约 400 种 HPV 类型。中国是HPV高负担国家之一，报告感染多种HPV类型，占全球死亡人数的17.3%，占全球新发病例的18.2%。因此，了解中国分离的HPV的遗传变异和地理多样性特征对于全球HPV预防策略至关重要。因此，我们分析了在中国分离的可用 HPV 基因组序列，根据全长基因组将其分为两类（α 乳头瘤病毒和 γ 乳头瘤病毒）。最常见的分别是 HPV-16、-6、-58 和 -52。此外，在中国分离出四种新菌株，例如TG550、JDFY01、CH2 和 L55 分别与 HPV-mSK 159、244、201 和 200 聚类。我们的系统地理学网络分析表明，L55、TG550和CH2分别与mSK 200、046和201在遗传上相同，而JDFY01单独出现，在五个突变步骤后与mSK-040连接。此外，我们在 HPV-6/11 类型的 E1、E2、E7、L1/L2 蛋白和长控制区 ORF 内发现了 10 个重组事件。我们获得了 HPV 蛋白的共有氨基酸序列，并在中国流行的所有 HPV 的 E5A 内发现了一段保守的氨基酸。这些发现为了解中国 HPV 的遗传关系、分布和进化提供了宝贵的见解，可能有助于采取有效的 HPV 预防措施。

Human papillomaviruses (HPVs) are widespread, sexually transmitted group of viruses that infect most individuals at some stage, causing genital warts and cancers. They are members of the Papillomaviridae family, which contains about 400 HPV types. China is among the high HPV burden countries with reported infections of multiple HPV types, accounting for 17.3% of global deaths and 18.2% of global new cases. Thus, understanding the genetic variation and geographic diversity characteristics of HPVs isolated in China is critical for global HPV prevention strategies. Thus, we analyzed the available HPV genome sequences isolated in China that grouped into two categories (alpha- and gamma-papillomaviruses) based on full-length genomes. The most common were HPV-16, -6, -58, and -52 respectively. In addition, four of the novel strains isolated in China, e.g. TG550, JDFY01, CH2, and L55 clustered with the HPV-mSK 159, 244, 201, and 200 respectively. Our phylogeographic network analysis indicated that the L55, TG550, and CH2 are genetically identical to the mSK 200, 046, and 201 respectively, while JDFY01 appeared separately, connected to the mSK-040 following five mutational steps. Also, we found ten recombination events among HPV-6/11 types within their E1, E2, E7, L1/L2 proteins, and Long Control Region ORFs. We achieved the consensus amino acid sequences of HPV proteins and found a conserved stretch of amino acids within E5A of all HPVs circulating in China. These findings offer valued insights into the genetic relationships, distribution, and evolution of the HPVs in China that may assist in adapting effective HPV preventive measures.