遗传相互作用在一个物种内是适应性的。杂交可以破坏这种物种特异性的遗传相互作用，并产生新的相互作用，从而改变杂交后代的整体适应性。杂种不相容性是指降低杂种整体存活率和不育性的退化遗传相互作用，是杂种中两个不同基因组组合的结果之一。在不同的剑尾鱼物种之间的选择性杂交中发现自发致死性肿瘤发生和潜在的遗传相互作用表明，致命的病理过程可能是由退化的遗传相互作用引起的。这种导致致命表型的遗传相互作用被认为可以屏蔽不同物种之间的基因流动。然而，某些剑尾鱼物种之间的杂交不会产生此类肿瘤。在这里，我们报告了一种剑尾属物种基因组中的基因座的鉴定，该基因座抑制来自不同物种的癌基因。我们的发现提供了对正常和病理性色素细胞发育、调节和混合不相容性分子机制的见解。© 2024 作者。色素细胞

Genetic interactions are adaptive within a species. Hybridization can disrupt such species-specific genetic interactions and creates novel interactions that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to degenerative genetic interactions that decrease the overall hybrid survival and sterility, is one of the results from combining two diverged genomes in hybrids. The discovery of spontaneous lethal tumorigenesis and underlying genetic interactions in select hybrids between diverged Xiphophorus species showed that lethal pathological process can result from degenerative genetic interactions. Such genetic interactions leading to lethal phenotype are thought to shield gene flow between diverged species. However, hybrids between certain Xiphophorus species do not develop such tumors. Here we report the identification of a locus residing in the genome of one Xiphophorus species that represses an oncogene from a different species. Our finding provides insights into normal and pathological pigment cell development, regulation and a molecular mechanism in hybrid incompatibility.© 2024 The Author(s). Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.