许多纯化的生物活性化合物、粗提物和精油已被证明具有有效的抗氧化、抗菌、抗炎和抗病毒特性，特别是在体外或计算机模拟中；然而，它们在体内的应用受到生物体吸收和分布不充分的阻碍。将这些植物化学物质掺入固体脂质纳米颗粒 (SLN) 或纳米结构脂质载体 (NLC) 中已显示出显着的进步，并代表了通过不同给药途径提高其生物利用度的可行方法。这篇综述讨论了 SLN 和 NLC 的潜在应用，负载生物活性源自植物的化合物可用于治疗多种疾病。还概述了这些脂质纳米颗粒的临床前开发，以及在市场上推出的必要条件。药用植物为制药行业及其客户带来了更多价值，导致许多研究探索其治疗方法潜在的。已经提出了几种源自植物的具有抗病毒、抗癌、神经保护、抗氧化和抗衰老特性的生物活性物质，并将其负载到脂质纳米颗粒中。体外和体内研究证实了 SLN/NLC 在提高多种生物活性物质的生物利用度方面的附加值。应考虑进行表面改性以增加其稳定性和目标传递。

Numerous purified bioactive compounds, crude extracts, and essential oils have demonstrated potent antioxidant, antimicrobial, anti-inflammatory, and antiviral properties, particularly in vitro or in silico; however, their in vivo applications are hindered by inadequate absorption and distribution in the organism. The incorporation of these phytochemicals into solid lipid nanoparticles (SLN) or nanostructured lipid carriers (NLC) has demonstrated significant advancements and represents a viable approach to improve their bioavailability through different administration routes.This review discusses the potential applications of SLN and NLC, loading bioactive compounds sourced from plants for the treatment of several diseases. An overview of the preclinical developments on the use of these lipid nanoparticles is also provided as well as the requisites to be launched on the market.Medicinal plants have gained even more value for the pharmaceutical industries and their customers, leading to many studies exploring their therapeutic potential. Several bioactives derived from plants with antiviral, anticancer, neuroprotective, antioxidant, and antiaging properties have been proposed and loaded into lipid nanoparticles. In vitro and invivo studies corroborate the added value of SLN/NLC to improve the bioavailability of several bioactives. Surface modification to increase their stability and target delivery should be considering.