放射性药物治疗诊断治疗在世界范围内呈指数级增长，内部剂量测定引起了人们的关注和资源。尽管与化疗有一些相似之处，但放射性药物治疗本质上是放射治疗，因为放射线释放到组织中是观察到的临床效果的决定因素。因此，吸收剂量计算是解释剂量效应相关性和个体化放射性药物治疗的关键。本文介绍了内部剂量测定的基本原理，并概述了中枢神经系统肿瘤可用的局部和全身放射性药物治疗。强调了应用于这些治疗的剂量测定的具体特征及其局限性和最相关的结果。与过去相比，剂量测定的精度更高，重现性更好，并且应该系统地收集剂量测定数据，因为治疗计划和验证可能有助于充分发挥中枢神经系统肿瘤治疗诊断的潜力。© 作者 2024。牛津大学出版大学出版社代表神经肿瘤学会。版权所有。如需商业重复使用，请联系 reprints@oup.com 获取转载和转载的翻译权。所有其他权限都可以通过我们网站文章页面上的权限链接通过我们的 RightsLink 服务获得 - 如需了解更多信息，请联系journals.permissions@oup.com。

Radiopharmaceutical theranostic treatments have grown exponentially worldwide, and internal dosimetry has attracted attention and resources. Despite some similarities with chemotherapy, radiopharmaceuticals treatments are essentially radiotherapy treatments, as the release of radiation into tissues is the determinant of the observed clinical effects. Therefore, absorbed dose calculations are key to explain dose-effect correlations and to individualize radiopharmaceutical treatments. The present article introduces the basic principles of internal dosimetry and provides an overview of available locoregional and systemic radiopharmaceutical treatments for CNS tumors. The specific characteristics of dosimetry as applied to these treatments are highlighted, along with their limitations and most relevant results. Dosimetry is performed with higher precision and better reproducibility than in the past, and dosimetric data should be systematically collected, as treatment planning and verification may help exploit the full potential of theranostic of CNS tumors.© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.