覆盖范围：2019年至2023年异喹啉生物碱是一类重要的氮基杂环化合物，引起了全世界研究人员的广泛关注。为了跟进我们之前的综述（涵盖 2014-2018 年）并展示此类化合物的进展，本综述总结并提供了 2019-2023 年期间分离的新型异喹啉生物碱的最新文献，以及它们的生物活性和潜在的研究进展。行动机制。此外，随着合成修饰策略的快速发展，异喹啉生物碱的合成策略不断优化，本文对此类天然产物的全合成进行了批判性综述。分离并讨论了 250 多种具有广泛生物活性的分子，包括抗肿瘤、抗菌、心脏保护、抗炎、神经保护和其他活性。提出了9类以上异喹啉生物碱的全合成，其中13个化合物为首次全合成。这项调查为从原始天然存在的异喹啉生物碱中发现新药提供了新的指示或可能性。

Covering: 2019 to 2023Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide. To follow up on our prior review (covering 2014-2018) and present the progress of this class of compounds, this review summarizes and provides updated literature on novel isoquinoline alkaloids isolated during the period of 2019-2023, together with their biological activity and underlying mechanisms of action. Moreover, with the rapid development of synthetic modification strategies, the synthesis strategies of isoquinoline alkaloids have been continuously optimized, and the total synthesis of these classes of natural products is reviewed critically herein. Over 250 molecules with a broad range of bioactivities, including antitumor, antibacterial, cardioprotective, anti-inflammatory, neuroprotective and other activities, are isolated and discussed. The total synthesis of more than nine classes of isoquinoline alkaloids is presented, and thirteen compounds constitute the first total synthesis. This survey provides new indications or possibilities for the discovery of new drugs from the original naturally occurring isoquinoline alkaloids.