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31P 多回波 MRSI,具有低 B1 双频带重聚焦射频脉冲。

31P multi-echo MRSI with low B1 + dual-band refocusing RF pulses.

发表日期:2024 Oct 10
作者: Zahra Shams, Wybe J M van der Kemp, Dennis W J Klomp, Evita C Wiegers, Jannie P Wijnen
来源: NMR IN BIOMEDICINE

摘要:

31P 磁共振波谱 (MRS) 可以对参与磷脂代谢的代谢物进行光谱解析,其水平在许多癌症中发生改变。超高场有助于检测磷酸单酯 (PME) 和磷酸二酯 (PDE),同时提高信噪比和光谱分辨率。利用多回波 MR 光谱成像 (MRSI) 进一步增强 SNR,并能够估计每个代谢物的 T2 信息。为了解决多回波磷成像中与高功率要求的绝热或复合块脉冲相关的比吸收率 (SAR) 挑战,我们提出了一种双频带重聚焦射频脉冲,设计用于在 14.8 μT 的 B1 幅度下运行,该脉冲具有整合到多回波序列中。在 7 Tesla 的大脑中进行的模型和体内实验验证了这种低功率双频射频脉冲的有效性。此外,我们将双频带 RF 脉冲实现到多回波 MRSI 序列中,与高功率绝热实现相比,它有可能在相同的采集时间内增加回波脉冲的数量,证明了其可行性和实用性。© 2024作者。约翰·威利 (John Wiley) 出版的《生物医学中的核磁共振》
31P magnetic resonance spectroscopy (MRS) can spectrally resolve metabolites involved in phospholipid metabolism whose levels are altered in many cancers. Ultra-high field facilitates the detection of phosphomonoesters (PMEs) and phosphodiesters (PDEs) with increased SNR and spectral resolution. Utilizing multi-echo MR spectroscopic imaging (MRSI) further enhances SNR and enables T2 information estimation per metabolite. To address the specific absorption rate (SAR) challenges associated with high-power demanding adiabatic or composite block pulses in multi-echo phosphorus imaging, we present a dual-band refocusing RF pulse designed for operation at B1 amplitudes of 14.8 μT which holds potential for integration into multi-echo sequences. Phantom and in vivo experiments conducted in the brain at 7 Tesla validated the effectiveness of this low-power dual-band RF pulse. Furthermore, we implemented the dual-band RF pulse into a multi-echo MRSI sequence where it offered the potential to increase the number of echo pulses within the same acquisition time compared to high-power adiabatic implementation, demonstrating its feasibility and practicality.© 2024 The Author(s). NMR in Biomedicine published by John Wiley & Sons Ltd.