纳米体是由非离子表面活性剂和胆固醇形成的双层囊泡组成的关键纳米载体，具有理化稳定性高、生物可降解性、成本效益和低毒性等优点。本综述讨论了它们在药物输送中的重要作用，包括在抗癌治疗和疫苗输送中的应用。它还强调了非离子表面活性剂对脂质体形成、药物输送途径和蛋白冠形成的影响——这是一个相对尚未充分探索的话题。此外，还研究了人工智能在优化纳米体设计和功能方面的应用。未来的研究方向包括提高制剂技术、扩大应用范围、整合先进技术。该综述为推进基于纳米体的药物输送系统提供了全面的见解和实践指导。© 2024 高等人。

Niosomes are key nanocarriers composed of bilayer vesicles formed by non-ionic surfactants and cholesterol, offering advantages such as high physicochemical stability, biodegradability, cost-effectiveness, and low toxicity. This review discusses their significant role in drug delivery, including applications in anticancer therapy and vaccine delivery. It also highlights the impact of non-ionic surfactants on niosome formation, drug delivery pathways, and protein corona formation-a relatively underexplored topic. Furthermore, the application of artificial intelligence in optimizing niosome design and functionality is examined. Future research directions include enhancing formulation techniques, expanding application scopes, and integrating advanced technologies. This review provides comprehensive insights and practical guidance for advancing niosome-based drug delivery systems.© 2024 Gao et al.