淋巴瘤患者循环肿瘤 DNA 的检测。
Detection of Circulating Tumor DNA in Lymphoma Patients.
发表日期：2025
作者：
Alessio Bruscaggin, Katia Pini, Davide Rossi
来源：
Experimental Hematology & Oncology
摘要：
液体活检已成为淋巴瘤诊断的一个机会，因为血浆循环肿瘤 DNA (ctDNA) 是肿瘤 DNA 的一种易于获取的来源，可以作为组织活检的补充。通过 ctDNA，可以对淋巴瘤进行分子表征，跟踪肿瘤克隆进化，同时监测治疗期间和治疗后的微小残留疾病。在这里，我们描述了通过深度测序 (CAPP-seq) 进行癌症个性化分析的方法，用于 ctDNA 鉴定和定量。© 2025。作者获得 Springer Science Business Media, LLC（Springer 旗下公司）的独家许可自然。
Liquid biopsy has become an opportunity in lymphoma diagnostics, since plasma circulating tumor DNA (ctDNA) is an easily accessible source of tumor DNA, which can be complementary to tissue biopsy. Through ctDNA, lymphomas can be molecularly characterized, tumor clonal evolution can be tracked, while monitoring minimal residual diseases during and after therapy. Here, we describe the methodology of cancer personalized profiling by deep sequencing (CAPP-seq) that we use for ctDNA qualification and quantification.© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.