最近在阐明果蝇模型中特定抗利尿激素的作用方面取得的进展为肿瘤诱发肾功能障碍的机制提供了有价值的见解。徐等人。确定了哺乳动物神经激肽 3 受体 (TACR3)（果蝇中 G 蛋白偶联受体 TkR99D 的同源物）作为缓解恶性肿瘤小鼠肾小管功能障碍的潜在治疗靶点。在这里，我们通过强调 TACR3 的结构和进化意义来评论这些发现，并深入分析了 TACR3 响应肾损伤的细胞类型特异性表达和肾癌进展过程中的表达动态。强调了这些发现对于改变与肿瘤疾病相关的肾脏并发症的治疗方法的意义。我们还承认本研究中当前实验模型的局限性，并强调未来必要的临床验证。这些见解可能有助于推进治疗肿瘤相关肾脏病理的诊断和治疗策略。© 2024。作者。

Recent progress in elucidating the role of specific antidiuretic hormones in Drosophila models has provided valuable insights into the mechanisms underlying tumor-induced renal dysfunction. Xu et al. identified the mammalian neurokinin 3 receptor (TACR3), a homolog of the G protein-coupled receptor TkR99D in fruit flies, as a potential therapeutic target for alleviating renal tubular dysfunction in mice with malignant neoplasms. Here, we commented on these findings by emphasizing the structural and evolutionary significance of TACR3 and provided an in-depth analysis of cell type specific expression of TACR3 in response to renal injury and expressional dynamics during renal carcinoma progression. The implications of these findings for transforming the therapeutic approaches to renal complications associated with oncological disorders were highlighted. We also acknowledged the limitations of current experimental models in this study and emphasized the necessary clinical validation in the future. These insights could contribute to the advancement of diagnostic and therapeutic strategies for treating tumor-related renal pathologies.© 2024. The Author(s).