妊娠区蛋白 (PZP) 是一种抗蛋白酶抗性免疫抑制剂，属于 α-巨球蛋白 (αM) 蛋白家族。 PZP 由肝脏分泌，并被发现在怀孕期间血浆中表达上调。 α-2-巨球蛋白 (α2M) 与 PZP 具有 71% 的序列同源性，但低 PZP 水平不会导致妊娠期 A2M 水平升高。 PZP 可以与多种因子相互作用，例如低密度脂蛋白受体相关蛋白 (LRP)、转化生长因子-β (TGF-β)、78kDa 葡萄糖调节蛋白 (GRP78) 和糖苷 A (GdA)。 PZP 参与糖脂代谢紊乱、支气管扩张、阿尔茨海默病 (AD)、类风湿性关节炎 (RA)、心肌梗死 (MI) 和炎症性肠病 (IBD) 的发生。 PZP 还与乳腺癌 (BC)、同源肝细胞癌 (HCC)、肺腺癌 (LAC) 和结直肠癌 (CRC) 等肿瘤发生的进展相关。因此，本综述分析了 PZP 在各种疾病病理生理学中的作用。版权所有 © 2024。由 Elsevier B.V. 出版。

Pregnancy zone protein (PZP) is an antiprotease-resistant immunosuppressant belonging to the α-macroglobulin (αM) protein family. PZP is secreted by the liver and was found to be upregulated in plasma during pregnancy. α-2-macroglobulin (Α2M) shares 71 % serial homology with PZP, but low PZP levels do not lead to increased A2M levels in pregnancy. PZP can interact with several factors such as low-density lipoprotein receptor-associated protein (LRP), transforming growth factor-β (TGF-β), 78 kDa glucose-regulated protein (GRP78), and glycoside A (GdA). PZP is involved in the development of glycolipid metabolism disorders, bronchiectasis, Alzheimer's disease (AD), rheumatoid arthritis (RA), myocardial infarction (MI) and inflammatory bowel disease (IBD). PZP is also associated with the progression of tumorigenesis such as breast cancer (BC), homologyepatocellular carcinoma (HCC), lung adenocarcinoma (LAC), and colorectal cancer (CRC). Therefore, this review analyzes the role of PZP in pathophysiology of various diseases.Copyright © 2024. Published by Elsevier B.V.