开发治疗胶质母细胞瘤的药物一直是一项重大挑战。在此，合成了一系列芳烃钌(II)配合物并作为抑制胶质母细胞瘤增殖和转移的潜在候选物进行了研究。研究发现，对位取代基修饰的分子，尤其是6位取代基的分子，比邻位取代基表现出更高的抗肿瘤活性。进一步研究表明6可以通过调节PI3K/AKT/mTOR通路触发肿瘤细胞自噬。此外，还发现6可以通过结合和稳定VEGF G-四链体DNA来诱导胶质母细胞瘤细胞中的DNA损伤。此外，在斑马鱼模型中证实6可以抑制U87-MG胶质母细胞瘤细胞原位异种移植的增殖和转移。因此，芳烃钌(II)络合物可以开发为未来治疗胶质母细胞瘤的有前途的治疗剂。

Developing drugs for treating glioblastoma has been a significant challenge. Herein, a series of arene ruthenium(II) complexes have been synthesized and investigated as potential candidates to suppress the proliferation and metastasis of glioblastoma. It is found that para-substituent-modified molecules, especially 6, exhibit higher antitumor activity than ortho-substituents. Further studies show that 6 can trigger tumor cell autophagy by regulating the PI3K/AKT/mTOR pathway. Moreover, it is also found that 6 can induce DNA damage in glioblastoma cells through binding and stabilizing VEGF G-quadruplex DNA. Furthermore, it is confirmed that 6 can inhibit the proliferation and metastasis of U87-MG glioblastoma cell in situ xenograft in the zebrafish model. Hence, arene ruthenium(II) complexes can be developed as promising therapeutic agents for glioblastoma treatment in the future.