该研究旨在评估现实生活中艾滋病毒感染者（PWH）吸烟暴露对主要临床事件（MCE）的影响。来自意大利的观察性纵向多中心队列研究。连续983名PWH入组“戒烟” HIV 人群”(STOPSHIV) 项目并于 2014 年 7 月至 2023 年 9 月进行跟踪。观察到的 MCE 定义为心血管 (CV) 事件、肿瘤疾病或任何原因的死亡，根据吸烟状况和相关变量（每日吸烟数量、包数）进行评估-年，Fagerström 测试）在参与者中。使用 Cox 比例风险模型（风险比、HR 和 95% CI）评估暴露变量与事件之间的关联。在 6997.6 人年的随访 (PYFU) 中，我们总共发现了 49 起心血管事件， 61 起肿瘤事件，47 人死亡。 MCE 的总体发生率为 17.6 /1000 PYFU（95% 置信区间 14.7-21.0）。全因死亡率为 6.7 (95% CI 5.0-8.9)/1000 PYFU。在多变量分析中，年龄较大（HR 1.07，CI 1.05-1.09），高 Fagerström 尼古丁依赖性测试（HR 1.09，CI 1.03-1.15），低最低 CD4 <200 细胞/mm3（HR 1.63，CI 1.10-1.41） )、既往肿瘤病史 (HR 2.41; CI 1.34-4.43) 和静脉吸毒作为 HIV 感染危险因素 (HR 2.36; CI 1.52-3.68) 是任何 MCE 的独立预测因子。非 AIDS 临床状况是观察最多的来自意大利的 PWH 临床事件。吸烟暴露会显着增加 PWH 中 MCE 的风险，而高 Fagerström 尼古丁依赖性测试是 MCE 的预测因子。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。

The study aimed to assess the impact of smoking exposure on major clinical events (MCE) in a real-life setting of people living with HIV (PWH).Observational longitudinal multicentre cohort study from Italy.Consecutive 983 PWH were enrolled in "STOP Smoking in HIV people" (STOPSHIV) projects and followed from July 2014 until September 2023. The observed MCE defined as cardiovascular (CV) events, neoplastic diseases or death for any reason was assessed according smoking status and related variables (number of cigarettes smoked daily, pack-years, Fagerström test) in participants. The association between exposure variables and the event was evaluated using the Cox proportional hazard model (hazard ratios, HR, and 95% CI).Over 6997.6 person-years of follow-up (PYFU), we found a total of 49 CV events, 61 neoplastic events, and 47 deaths. The overall incidence rate of MCE was 17.6 /1000 PYFU (95% confidence interval 14.7-21.0). All-cause death rate was 6.7 (95% CI 5.0-8.9)/1000 PYFU. In a multivariate analysis, older age (HR 1.07, CI 1.05-1.09), high Fagerström Test for Nicotine Dependence (HR 1.09, CI 1.03-1.15), a low nadir CD4 <200 cells/mm3 (HR 1.63, CI 1.10-1.41), history of previous neoplasm (HR 2.41; CI 1.34-4.43) and intravenous drug use as risk factor for HIV infection (HR 2.36; CI 1.52-3.68) were independent predictors of any MCE.Non-AIDS clinical conditions are the most observed clinical events in PWH from Italy. Smoking exposure significantly increases the risk of MCE in PWH and a high Fagerström Test for Nicotine Dependence is a predictor of MCE.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.