铁死亡是一种受调节的细胞死亡，是由于脂质中致命活性氧 (ROS) 的铁依赖性积累而发生的。铁死亡具有独特的形态、生化和遗传特征，使其有别于其他调节性细胞死亡 (RCD) 类型，包括细胞凋亡、各种坏死类型和自噬。最近的报告表明，铁蛋白的形成与许多疾病相关，例如急性损伤、梗塞、炎症和癌症。铁吸收障碍也与肠上皮功能障碍有关，特别是炎症性肠病（IBD）。对铁吸收障碍的研究可能为 IBD 的发病机制提供新的见解，从而提高医疗干预的效果。本综述对铁死亡进行了概述，阐明了其基本机制，并强调了其在 IBD 中的重要作用。版权所有 © 2024 Xie、Cao、Shu、Liu 和 Zhang。

Ferroptosis is a type of regulated cell death that occurs due to the iron-dependent accumulation of lethal reactive oxygen species (ROS) from lipids. Ferroptosis is characterized by distinct morphological, biochemical, and genetic features that differentiate it from other regulated cell death (RCD) types, which include apoptosis, various necrosis types, and autophagy. Recent reports show that ferritin formation is correlated to many disorders, such as acute injury, infarction, inflammation, and cancer. Iron uptake disorders have also been associated with intestinal epithelial dysfunction, particularly inflammatory bowel disease (IBD). Studies of iron uptake disorders may provide new insights into the pathogenesis of IBD, thereby improving the efficacy of medical interventions. This review presents an overview of ferroptosis, elucidating its fundamental mechanisms and highlighting its significant involvement in IBD.Copyright © 2024 Xie, Cao, Shu, Liu and Zhang.