使用动态刺激响应超分子化学传感器检测癌症的最新进展。重点审查。
Recent advances in cancer detection using dynamic, stimuli-responsive supramolecular chemosensors. a focus review.
发表日期:2024
作者:
Kotaro Matsumoto, Keiichi Nakagawa, Daisuke Asanuma, Gaku Fukuhara
来源:
PHARMACOLOGY & THERAPEUTICS
摘要:
在当前化学中,对溶剂、温度、光激发、pH和机械力(压力、应力、应变和张力)等多种外部刺激做出响应的超分子材料引起了人们的广泛关注。例如,我们开发了环糊精、葫芦脲、柱芳烃、杯芳烃、基于冠醚的化学传感器或化学传感器。这些超分子化学传感器在成像、探测和癌症检测方面具有潜在的应用。最近,我们从癌症治疗的角度关注压力,特别是溶液状态静水压。这篇迷你评论总结了 (i) 为什么静水压很重要,特别是在生物学中,以及 (ii) 我们可以使用静水压刺激做什么。版权所有 © 2024 Matsumoto、Nakakawa、Asanuma 和 Fukuhara。
In current chemistry, supramolecular materials that respond to a wide variety of external stimuli, such as solvents, temperature, light excitation, pH, and mechanical forces (pressure, stress, strain, and tension), have attracted considerable attention; for example, we have developed cyclodextrins, cucurbiturils, pillararenes, calixarenes, crown ether-based chemical sensors, or chemosensors. These supramolecular chemosensors have potential applications in imaging, probing, and cancer detection. Recently, we focused on pressure, particularly solution-state hydrostatic pressure, from the viewpoint of cancer therapy. This Mini Review summarizes (i) why hydrostatic pressure is important, particularly in biology, and (ii) what we can do using hydrostatic pressure stimulation.Copyright © 2024 Matsumoto, Nakagawa, Asanuma and Fukuhara.