放射治疗宫颈癌或子宫内膜癌后慢性放射性肠炎的发生率及其对生活质量的影响。
The prevalence of chronic radiation enteritis following radiotherapy for cervical or endometrial cancer and its impact on quality of life.
发表日期:2009 Sep
作者:
J Abayomi, J Kirwan, A Hackett
来源:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
摘要:
研究表明,50%的人可能患有慢性辐射性肠炎(CRE)(Andreyev,J.,2005年。盆腔放疗的肠胃并发症:它们是否重要?Gut 54,1051-1054)。Gami等人(Gami,B.,Harrington,K.,Blake,P.,Dearnaley,D.,Andreyev,H.J.N.,2003年。骨盆放疗后如何治疗患者的肠胃症状。营养药理和治疗18,987-994)认为如果生活质量没有受影响,则这是不重要的。本研究的目的是确定有多少妇女在放射治疗后患有CRE,并研究接受更高剂量放疗或癌症处于更晚期的妇女是否更容易受到影响。
要求完成了宫颈癌或子宫内膜癌的放疗的妇女(= 117)被要求填写一个经过验证的问卷,探讨肠道问题和生活质量。所得分数与已知肠梗阻的妇女(Bugg,G.J.,Kiff,E.S.,Hosker,G.,2001年。一份新的特定于疾病的健康相关生命质量问卷,用于评估肛门失禁的女性。英国妇产科学杂志108(10),1057-1067)的分数相比较。使用“0”得分表明没有症状,47%的妇女获得了指示CRE的分数(> 0),范围20-85(平均值34,SD 14.4)。年龄较小的妇女(p <0.001)和宫颈癌患者(p <0.05)更有可能得CRE的得分。得分与放疗剂量或癌症阶段之间没有显著关系。
评分表明,接受放疗治疗的妇女中约有一半会发展CRE。生活质量受到影响,特别是由于缺乏CRE的警示信号而导致的疲劳和应对行为。
Studies suggest that 50% of people may suffer from chronic radiation enteritis (CRE) (Andreyev, J., 2005. Gastrointestinal complications of pelvic radiotherapy: are they of any importance? Gut 54, 1051-1054). Gami et al. (Gami, B., Harrington, K., Blake, P., Dearnaley, D., Andreyev, H.J.N., 2003. How patients manage gastrointestinal symptoms after pelvic radiotherapy. Alimentary Pharmacology and Therapeutics 18, 987-994) argue that this is unimportant if quality of life is unaffected. The aim of this study was to identify how many women experience CRE following radiotherapy and to investigate whether women who have higher doses of radiotherapy or more advanced stage of cancer are more at risk.Women (=117) who had completed radiotherapy for cervical or endometrial cancer were asked to complete a validated questionnaire exploring bowel problems and quality of life. Responses were scored and compared to scores for women with known faecal incontinence (Bugg, G.J., Kiff, E.S., Hosker, G., 2001. A new condition-specific health-related quality of life questionnaire for the assessment of women with anal incontinence. British Journal of Obstetrics and Gynaecology 108 (10), 1057-1067).Using a score of '0' to indicate no symptoms, 47% of women gained scores indicative of CRE (>0), range 20-85 (mean 34, SD 14.4). Younger women (p<0.001) and women with cervical cancer (p<0.05) were more likely to score for CRE. No significant relationship was observed between score and either radiotherapy dose or stage of cancer.Scoring suggests that about half of woman treated with radiotherapy develop CRE. Quality of life is affected, particularly regarding tiredness and coping behaviours due to lack of warning signs for CRE.