背景：急性髓细胞白血病（AML）是成人中最普遍的急性白血病。骨髓血管生成对于白血病发病机制至关重要，并且AML患者的骨髓均衡血管密度（MVD）和血管生成因子水平的增加。根据以前的研究，骨髓MVD水平与AML的预后不良有关。本研究旨在比较AML患者和对照组的骨髓MVD，并评估AML治疗后残留爆炸细胞数量与骨髓MVD之间的关系。 材料和方法：本研究是对入院Omid医院的AML患者进行的纵向研究。从病理实验室的档案中获取了AML患者和正常诊断患者（对照组）的骨髓活检。对所有标本进行免疫组化染色，使用凝血调节蛋白作为标记来计算MVD。评估AML患者的流式细胞术结果，确定AML患者组中MRD的百分比。 结果：本研究评估了27名AML患者和24名年龄平均为40.92±15.13岁的健康个体，其中56.86％为男性。AML患者的骨髓平均MVD显著高于对照组。男性的平均骨髓MVD显著高于女性，骨髓MVD与MRD之间存在不显著的负相关。约59.3％的AML患者对治疗有反应，MVD与治疗反应之间没有显著关系。 结论：AML患者的骨髓MVD高于对照组，骨髓MVD与MRD和治疗反应之间没有显著关系。版权：©国际血液学、肿瘤学和干细胞研究杂志和伊朗医学科学大学。

Background: Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults. Bone marrow angiogenesis is crucial for pathogenesis of leukemia, and increasing bone marrow Mean Vascular Density (MVD) and level of angiogenesis factors are seen in patients with AML. Higher level of bone marrow MVD is associated with poor prognosis of AML according to previous studies. The present study aimed to compare bone marrow MVD in AML patients and controls and evaluate the relation between bone marrow MVD and number of residual blast cells after AML treatment. Materials and Methods: This study is a longitudinal study on AML patients who were admitted to Omid hospital. The bone marrow biopsies of patients with AML and patients with normal diagnosis -as control group- were taken from archives of pathology laboratory. Immunohistochemistry staining was used for all specimens by using thrombomodulin markers for calculating MVD. Flow cytometry findings of AML patients were assessed for percent of minimal residual disease (MRD) after AML treatment in AML patients group. Results: In this study, 27 AML patients and 24 healthy individuals with mean age of 40.92±15.13 years were evaluated, of whom 56.86% were male. The mean bone marrow MVD was significantly higher in AML patients than controls. The mean bone marrow MVD was significantly higher in males and there was insignificant reverse correlation between bone marrow MVD and MRD. About 59.3% of AML patients had response to treatment and there was no significant relationship between MVD and response to treatment. Conclusion: Bone marrow MVD was higher in AML patients than controls and there was no remarkable relationship between bone marrow MVD and MRD and response to treatment.Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences.