引言 子宫内膜癌（ECs）是最常见的妇科恶性肿瘤。基于形态和发病机制，ECs分为1型和2型。1型ECs是那些由雌激素驱动的肿瘤，而2型ECs更具侵袭性，不受激素状态的影响。在本研究中，我们评估了2型ECs的临床病理参数，并与1型ECs进行了比较。 方法 我们回顾性地分析了Liaquat National Hospital病理档案馆从2013年1月至2019年12月的七年数据。所有患者均接受了子宫内膜活检诊断EC的根治性手术。所有标本均为全腹腔子宫切除术伴双侧输卵管卵巢切除术、系膜切除术和腹膜取样，以及盆腔淋巴结清扫术。评估了肿瘤类型、分级、子宫肌层浸润深度以及卵巢、系膜、淋巴结和子宫旁组织的受累情况的记录。 结果 共纳入了129例ECs病例。患者的平均年龄为57.6±9.3岁。绝大多数病例为1型ECs（82.2％）。EC的最常见组织学类型是内膜样癌（82.2％），其次是浆液性癌（10.1％）。大多数肿瘤为1级（42.6％）和国际妇产科联合会（FIGO）I期（72.8％）。淋巴结转移存在于8例（6.2％）中，卵巢受累存在于12例（9.3％）中。我们发现EC类型与淋巴血管侵犯、淋巴结转移和卵巢受累之间存在显着的相关性，而EC类型与其他临床病理特征没有显着相关性。 结论 1型EC是我们研究中最常见的EC亚型。另一方面，2型EC与淋巴结转移、淋巴血管侵犯和卵巢受累显着相关，表明这一类EC的不良预后意义显著。版权所有©2020，Hashmi等。

Introduction Endometrial cancers (ECs) are the most common gynecological malignancies. Based on morphology and pathogenesis, ECs are segregated into type 1 and 2 ECs. Types 1 ECs are those tumors that are estrogen-driven, whereas type 2 ECs are more aggressive and are independent of hormonal status. In the proposed study, we evaluated the clinicopathological parameters of type 2 ECs and its comparison with type 1 ECs. Methods We retrospectively analyzed seven-year data from archives of pathology, Liaquat National Hospital, from January 2013 to December 2019. All patients underwent radical surgeries for diagnosed EC on endometrial biopsy. All specimens were of total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy, and peritoneal sampling, along with pelvic lymphadenectomy. Records regarding tumor type, grade, depth of myometrial invasion, and ovarian, omental, nodal, and parametrial involvement were assessed. Results A total of 129 cases of ECs were included in the study. The mean age of the patients was 57.6 ± 9.3 years. Majority of the cases were type 1 ECs (82.2%). The most common histological type of EC was endometrioid (82.2%) followed by serous carcinoma (10.1%). Most of the tumors were grade 1 (42.6%) and the International Federation of Gynecology and Obstetrics (FIGO) stage I (72.8%). Nodal metastases were present in eight cases (6.2%) and adnexal involvement was present in 12 cases (9.3%). We found a significant association of the type of EC with lymphovascular invasion, nodal metastasis, and adnexal involvement, whereas no significant association of EC type was seen with other clinicopathological characteristics. Conclusions Type 1 EC was the most frequent subtype of EC in our study. On the other hand, type 2 EC was significantly associated with nodal metastasis, lymphovascular invasion, and adnexal involvement, signifying the poor prognostic significance of this group of EC.Copyright © 2020, Hashmi et al.