背景 原发性外周淋巴瘤在常规实践中较少见，且难以诊断。除了临床细节外，组织病理学和免疫组化研究对诊断至关重要。在印度的不同地区，发病率以及组织病理学谱系的变异也不同。 方法 检索了病理科档案中3年期间确诊为原发性外周淋巴瘤的患者的临床特征和组织病理学结果，并进行分析。 结果 在3年的研究期间，共评估了135例非霍奇金淋巴瘤病例，其中41.4％（56/135）的病例表现为原发性外周淋巴瘤。原发性外周淋巴瘤的平均发病年龄为61.3±17.5岁，男女比例为1:1.1。最常见的外周部位涉及是胃肠道，占32.1％（18/56）（小肠[17.8％，10例]和大肠[8.9％，5例]）。B细胞型非霍奇金淋巴瘤是优势亚型（48/56，85.7％），而T细胞谱系的病例占8/56（14.2％）。在B细胞非霍奇金淋巴瘤中，弥漫性大B细胞淋巴瘤是主要亚型，约占83.3％（40/48）。 结论 原发性外周淋巴瘤表现出多样的组织形态学和临床表现。本研究是旨在与印度其他地区的研究进行比较的旁遮普邦的首次分析。 MedIntel Services Pvt Ltd.本是Thieme发布的开放获取文章，按照知识共享署名-非衍生-非商业许可协议的条款，允许复制和重制，只要原始工作得到适当的信用。本文内容不得用于商业目的，不得被改编、混合、转化或构建。 (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Background  Primary extranodal lymphomas are less frequently encountered and difficult to diagnose in routine practice. The histopathological and immunohistochemical studies are essential in addition to clinical details to diagnose. The incidence is varied in different parts of India along with variation in histopathological spectrum. Methodology  The clinical features and histopathological findings of patients diagnosed with primary extranodal lymphoma over 3-year period were retrieved from archives of pathology department and analyzed. Results  During the 3-year study period, a total of 135 cases of non-Hodgkin lymphomas were evaluated, and of these, 41.4% (56/135) of cases presented with primary extranodal involvement. The mean age of primary extranodal lymphoma presentation was 61.3 ± 17.5 with M:F ratio of 1:1.1 Most common extranodal site involved was gastrointestinal tract 32.1%, 18/56 (small intestine [17.8%, 10 cases] and large intestine [8.9%, 5 cases]). Non-Hodgkin lymphomas of B cell type were the predominant subtype (48/56, 85.7%), while 8/56 (14.2%) cases were of T cell lineage. Of the B cell non-Hodgkin lymphoma diffuse, large B cell lymphoma was the predominant subtype constituting ~83.3% (40/48). Conclusion  Primary extranodal lymphomas exhibit varied histomorphological and clinical presentation. The present study is first such analysis from Punjab that intends to compare with studies from other parts of India.MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).