胰腺型核糖核酸酶（ptRNases）是一大类仅存在于脊椎动物体内的外分泌内切核糖核酸酶。这些酶能够催化多种RNA底物的降解，从而参与多种生物功能的调节。虽然ptRNases同源性信息可用于其生化特性和进化分析，但对其生物学作用的认识仍不完整。在这里，我们回顾了两种ptRNases的功能：RNase 1和血管生成素。RNase 1是一种催化活性高、且含量较多的ptRNase，最新发现它在炎症和血凝方面具有一定作用。血管生成素则能促进新血管生成，在癌症和肌萎缩侧索硬化等疾病的进展以及细胞应激反应中也有作用。目前的研究正揭示这些及其他ptRNases的生物学特性。

Pancreatic-type ribonucleases (ptRNases) are a large family of vertebrate-specific secretory endoribonucleases. These enzymes catalyze the degradation of many RNA substrates and thereby mediate a variety of biological functions. Though the homology of ptRNases has informed biochemical characterization and evolutionary analyses, the understanding of their biological roles is incomplete. Here, we review the functions of two ptRNases: RNase 1 and angiogenin. RNase 1, which is an abundant ptRNase with high catalytic activity, has newly discovered roles in inflammation and blood coagulation. Angiogenin, which promotes neovascularization, is now known to play roles in the progression of cancer and amyotrophic lateral sclerosis, as well as in the cellular stress response. Ongoing work is illuminating the biology of these and other ptRNases.